Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Angulo, Javier; Assar, Mariam El; Rodríguez‐Mañas, Leocadio

doi:10.1016/j.mam.2016.06.001

Cited by 127 publications

(80 citation statements)

References 472 publications

(493 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The strength of respiratory muscles, compliance of the chest wall, and static elastic recoil all progressively decline with aging, making the lungs less resistant to environmental insults such as infectious agents and pollutants. 26,27 Older adults are also at an increased risk of aspiration pneumonia. Aging is associated with a higher incidence of dysphagia which can lead to aspiration as a result of misdirection of oropharyngeal secretions with a high bacterial load or gastric material into the lower respiratory tract.…”

Section: Pathophysiologic Factors Influencing Infection Risk and Pmentioning

confidence: 99%

Influence of Aging and Environment on Presentation of Infection in Older Adults

Chakhtoura

Bonomo

Jump

2017

Infectious Disease Clinics of North America

View full text Add to dashboard Cite

Synopsis In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age related organ-specific physiologic changes, and frailty. We also describe clinical factors influencing infection risk and presentation in older adults including temperature regulation, cognitive decline, and malnutrition. Finally, we discuss the influence of the setting in which older adults reside on the clinical evaluation of infection. Understanding the influence of all these changes may facilitate the prevention, early recognition and treatment of infections in older adults.

show abstract

Section: Pathophysiologic Factors Influencing Infection Risk and Pmentioning

confidence: 99%

Influence of Aging and Environment on Presentation of Infection in Older Adults

Chakhtoura

Bonomo

Jump

2017

Infectious Disease Clinics of North America

View full text Add to dashboard Cite

show abstract

“…Frailty is a part of geriatric syndrome, and has been described as a loss of ability to adapt to stress due to diminished functional reserves 1–3. The condition can be considered a pre-disability state 1.…”

Section: Introductionmentioning

confidence: 99%

“…The condition can be considered a pre-disability state 1. In frail patients, exposure to stressors can lead to several serious outcomes including procedural complications, institutionalization, fractures, disability, and death.…”

Section: Introductionmentioning

confidence: 99%

Frailty syndrome in ambulatory patients with COPD

Limpawattana¹,

Putraveephong²,

Inthasuwan³

et al. 2017

COPD

View full text Add to dashboard Cite

Frailty is a state of increased risk of unfavorable outcomes when exposed to stressors, and COPD is one of the several chronic illnesses associated with the condition. However, few studies have been conducted regarding the prevalence of COPD and its related factors in Southeast Asia. The objectives of this study were to determine the prevalence of frailty in COPD patients and to identify the associated factors in these populations. A cross-sectional study of COPD patients who attended a COPD clinic was conducted from May 2015 to December 2016. Baseline characteristics were collected, and the diagnosis of frailty was based on the FRAIL (fatigue, resistance, ambulation, illnesses, and loss of weight) scale. Descriptive statistics were used to analyze baseline data. Factors associated with frailty were analyzed using univariate and multivariate regression analyses. The results showed that the prevalence rates of frailty and pre-frailty were 6.6% (eight out of 121 cases) and 41.3% (50 out of 121 cases), respectively, among COPD patients. Fatigue was the most common component of the FRAIL scale that was found more frequently in frail patients than in non-frail patients (odds ratio [OR] 91.9). Factors associated with frailty according to multivariate analyses were comorbid cancer (adjusted OR [AOR] 45.8), at least two instances of nonelective admission over the past 12 months (AOR 112.5), high waist circumference (WC) (AOR 1.3), and presence of sarcopenia (AOR 29.5). In conclusion, frailty affected 6.6% of stable COPD patients. Cancer, two or more instances of nonelective hospitalization over the past 12 months, high WC, and presence of sarcopenia were associated with frailty. Early identification and intervention in high-risk patients is recommended to prevent or delay the adverse outcomes of frailty.

show abstract

“…15,17,154,[175][176][177] Furthermore, sarcopenia is directly related to low serum T 178 and takes part to the physiological process of aging itself. [179][180][181] Even chronic illnesses are able to induce sarcopenia. 180,182 Thus it is evident that sarcopenia should be considered as a central player in the relationships among LOH, frailty, and comorbidities.…”

Section: Hypogonadism and Non-infectious Comorbiditiesmentioning

confidence: 99%

“…[179][180][181] Even chronic illnesses are able to induce sarcopenia. 180,182 Thus it is evident that sarcopenia should be considered as a central player in the relationships among LOH, frailty, and comorbidities. 181 Aging, hypogonadism, and infectious diseases.…”

Section: Hypogonadism and Non-infectious Comorbiditiesmentioning

confidence: 99%

Aging and sex hormones in males

2016

View full text Add to dashboard Cite

Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments.

show abstract

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Cited by 127 publications

References 472 publications

Influence of Aging and Environment on Presentation of Infection in Older Adults

Influence of Aging and Environment on Presentation of Infection in Older Adults

Frailty syndrome in ambulatory patients with COPD

Aging and sex hormones in males

Contact Info

Product

Resources

About