Reference range of complete blood count, Ret-He, immature reticulocyte fraction, reticulocyte production index in healthy babies aged 1–4 months

Abstract

Establishing reference ranges of the complete blood count (CBC), reticulocyte hemoglobin content (Ret-He), immature reticulocyte fraction (IRF), and reticulocyte production index (RPI) helps diagnose a disease related to the changes in erythrocyte indices, white blood count, platelets, and reticulocytes, especially in babies. Therefore, the study aims to establish a reference range for CBC and reticulocyte parameters in healthy babies aged 1–4 months. The study design was a cross-sectional study with descriptive analysis of CBC and reticulocyte in babies aged 1–4 months. Three hundred forty-eight babies met the inclusion criteria. This study recruited 89 babies aged 1 month, 87 babies aged 2 months, 86 babies aged 3 months, and 86 babies aged 4 months. The P5-P95 reference range of healthy babies for hemoglobin (Hb) aged 1 month, 2 months, 3 months, and 4 months was 9.95 to 15.45 g/dL, 9.74 to 13.42 g/dL, 9.51 to 12.40 g/dL, and 10.04 to 13.10 g/dL respectively. The P3-P97 reference range of healthy babies for Hb aged 1 month, 2 months, 3 months, and 4 months was 9.60 to 15.90 g/dL, 9.46 to 13.97 g/dL, 9.26 to 12.82 g/dL, and 10.00 to 13.33 g/dL respectively. This study also defined reference ranges for CBC, Ret-He, IRF, and RPI. The reference range of CBC, Ret-He, IRF, and RPI for healthy babies aged 1–4 months in this study can be used as a benchmark.

Infantile pyknocytosis, a neonatal hemolytic anemia with Heinz bodies: A cohort study

“…Before transfusion, hemoglobin mean nadir was 78 g/L (range: 40–114 g/L) and was reached at Day (D)13 in average (range: D1–D25). Mean corpuscular volume and mean corpuscular hemoglobin concentration were strictly normal for age in all cases 17–19 . Reticulocytosis (defined by a reticulocyte count >150G/L) was inconstant at the time of anemia (Table 1).…”

“…Mean corpuscular volume and mean corpuscular hemoglobin concentration were strictly normal for age in all cases. [17][18][19] Reticulocytosis (defined by a reticulocyte count >150G/L) was inconstant at the time of anemia (Table 1). All children had normal white blood cell count (seven missing).…”

Usefulness of baseline immature reticulocyte fraction to mature reticulocyte fraction ratio (IMR) as A prognostic predictor for patients with small cell lung cancer

“…It is easier to obtain, can be put into clinical use immediately, does not require long-term verification such as scientific research experiments, and greatly reduces the cost of testing and many other advantages. IRF refers to the proportion of young reticulocytes, which reflects erythropoietic activity and is the first sign of blood recovery [ 35 , 36 ]. The quantitative and morphological characteristics of reticulocytes are associated with the aggressiveness of the tumor and the more severe clinical status of the patient [ 37 ].…”

The mean reticulocyte volume is a valuable index in early diagnosis of cancer-related anemia

“…Conventionally, iron deficiency diagnosis is based on determining ferritin, transferrin saturation, and soluble transferrin receptor, but these biomarkers are strongly influenced by inflammation and infection ( Ringoringo et al, 2023 ). RHE and RPI have been recognized the sensitive indices in the diagnosis of anemia.…”