Reference intervals of biochemical bone turnover markers for Saudi Arabian women: A cross-sectional study

Ardawi, M. S. M.; Maimani, A. A.; Bahksh, Talal A.; Rouzi, Abdulrahim A.; Qari, Mohammed H.; Raddadi, R.M.

doi:10.1016/j.bone.2010.07.017

Cited by 63 publications

(60 citation statements)

References 71 publications

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“…BTMs (s-OC, s-P1NP, s-bone ALP, p-CTx, u-CTx, and u-NTx) were measured as described. (21) Serum creatinine, calcium, phosphate, and magnesium were measured as described. (18) Serum 25-hydroxyvitamin-D [25(OH)D] was measured by direct competitive chemiluminescence immunoassay (CLIA) using a LIASON autoanalyzer (DiaSorin Inc., Stillwater, MN, USA).…”

Section: Assessment Of Bmdmentioning

confidence: 99%

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

Ardawi

Rouzi

Al-Sibiani

et al. 2012

Journal of Bone and Mineral Research

128

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Sclerostin regulates bone formation by inhibiting Wnt pathway signaling. Low circulating sclerostin levels cause high bone mass. We hypothesized that postmenopausal women with increased sclerostin levels have a greater risk for osteoporosis-related fractures. We examined the association between circulating sclerostin together with bone turnover markers and osteoporosis-related fracture risk in 707 postmenopausal women, in a population-based study with a mean follow-up period of 5.2 AE 1.3 years. Multivariate Cox proportional hazards regression models were used to analyze fracture risk, adjusted for age, body mass index, and other confounding risk factors. High sclerostin levels were strongly associated with increased fracture risk. After adjustment for age and other confounders, the relative fracture risk was more than sevenfold among postmenopausal women for each 1-SD increment increase in sclerostin level. Women in the highest quartile of sclerostin levels had about a 15-fold increase in fracture risk. Results were similar when we compared sclerostin at the 1-year visit to an average of two to three annual measurements. Fracture risk attributable to sclerostin levels was 56.6% in the highest quartile. Only high levels of bone resorption markers (plasma cross-linked C-terminal telopeptide of type 1 collagen [p-CTx], urinary CTx [u-CTx], and urinary N-telopeptide of type 1 collagen [u-NTx]) were predictive of osteoporosis-related fractures but at much lower hazard ratio (HR) values than that of serum sclerostin. Associations between sclerostin levels and fracture risk were independent of bone mineral density and other confounding risk factors. High sclerostin levels are a strong and independent risk factor for osteoporosis-related fractures among postmenopausal women. ß

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Section: Assessment Of Bmdmentioning

confidence: 99%

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

Ardawi

Rouzi

Al-Sibiani

et al. 2012

Journal of Bone and Mineral Research

128

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“…The RIs for many different common analytes in healthy Saudi individuals were investigated previously [6][7][8][9]. The most comprehensive study investigated RIs for general chemistry analytes was published by EL Hazmi in 1982 [10].…”

Section: Introductionmentioning

confidence: 99%

Establishment of reference intervals of clinical chemistry analytes for the adult population in Saudi Arabia: a study conducted as a part of the IFCC global study on reference values

Borai

Ichihara

Masaud

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: This study is a part of the IFCC-global study to derive reference intervals (RIs) for 28 chemistry analytes in Saudis. Method: Healthy individuals (n = 826) aged ≥ 18 years were recruited using the global study protocol. All specimens were measured using an Architect analyzer. RIs were derived by both parametric and non-parametric methods for comparative purpose. The need for secondary exclusion of reference values based on latent abnormal values exclusion (LAVE) method was examined. The magnitude of

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“…(20)(21)(22) There may be other factors influencing serum osteocalcin concentrations such as the use of oral contraceptives (23,24) hormone replacement therapy (25) and BMI. (26) Furthermore, serum osteocalcin concentrations were reported to be increased for short term by calcium intake.…”

Section: Discussionmentioning

confidence: 99%

Serum Osteocalcin Level in Type 2 Diabetes and Its Relation to the Severity of Coronary Heart Disease, Insulin Resistance and High Sensitive-CRP

Lachine¹

2017

jmscr

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Reference intervals of biochemical bone turnover markers for Saudi Arabian women: A cross-sectional study

Cited by 63 publications

References 71 publications

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

Establishment of reference intervals of clinical chemistry analytes for the adult population in Saudi Arabia: a study conducted as a part of the IFCC global study on reference values

Serum Osteocalcin Level in Type 2 Diabetes and Its Relation to the Severity of Coronary Heart Disease, Insulin Resistance and High Sensitive-CRP

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