Establishment of reference intervals of clinical chemistry analytes for the adult population in Saudi Arabia: a study conducted as a part of the IFCC global study on reference values

Abstract

Background: This study is a part of the IFCC-global study to derive reference intervals (RIs) for 28 chemistry analytes in Saudis. Method: Healthy individuals (n = 826) aged ≥ 18 years were recruited using the global study protocol. All specimens were measured using an Architect analyzer. RIs were derived by both parametric and non-parametric methods for comparative purpose. The need for secondary exclusion of reference values based on latent abnormal values exclusion (LAVE) method was examined. The magnitude of

Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China

“…As compared to Turkey's and Saudi Arabia's 31 multicenter study which used the same protocol with us, the RIs of TP, Alb, CRE, Glu, Na, K, Cl, Ca, IP, and Mg, Fe, LDH, ALP, GGT are close with each other. Among the 3 countries, Turkey has a highest lipids level, and Saudi Arabia has the lowest ALT level, which appear to be mainly due to difference in ethnicity and life style, and partly due to diffences in assay systems.…”

A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

“…As a method for secondary exclusion of RVs to cope with a high prevalence of latent anaemia, the LAVE method was applied by allowing one abnormal result in 7 reference test items (Hb, Hct, MCV, Fe, UIBC, TIBC, and ferritin) which reflect anaemic disorders ( 15 - 17 ). Thus, the RIs were derived in two ways, either with or without the LAVE method.…”

“…Thus, the RIs were derived in two ways, either with or without the LAVE method. The choice between the two RIs was made by the ratio of the difference in the two LLs (or ULs) to the SD comprising the RI, which corresponds to between-individual SD (SD BI ), as follows ( 17 ):…”

Analytical Bias Exceeding Desirable Quality Goal in 4 out of 5 Common Immunoassays: Results of a Native Single Serum Sample External Quality Assessment Program for Cobalamin, Folate, Ferritin, Thyroid-Stimulating Hormone, and Free T4 Analyses

“…There is a need for standardization or at least harmonization of reference intervals for different immunoassays (16 ). A step in the right direction is the United Kingdom Pathology harmony initiative (18 ) and the IFCC launching of an initiative to establish reference intervals in different ethnic populations in several countries in America, Asia, Africa, and Europe (3)(4)(5). It is encouraging that the study includes all common clinical-chemistry components and also suggests a procedure for later correlation and transfer of data to different measurement procedures.…”

“…The scope of external quality assessment (EQA) 4 has evolved considerably during recent years (2 ). With the increasing worldwide concern about the use of common reference intervals and medical decision limits (1,(3)(4)(5), modern EQA schemes should aim at assessing the standardization and harmonization status of commercial in vitro diagnostic tests. A prerequisite is the use of commutable EQA samples, i.e., samples that demonstrate the same numeric relationship between measurement procedures as is observed in real patient samples.…”