Reference air kerma rate calibration system for high dose rate Ir-192 brachytherapy sources in Taiwan

Chu, Wei-Han; Yuan, Ming-Chen; Lee, Jeng-Hung; Lin, Yi-Chun

doi:10.1016/j.radphyschem.2017.02.044

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…As with any invasive procedure, the outcomes are dependent on the skill of the physician, and positional variations in the placement of the needles can compromise treatment efficacy. , Furthermore, the dose delivery can be susceptible to errors in the calibration of the radioactive source. For instance, 192 Ir, which has a half-life of 74 days, requires monitoring before and during the time of the implant to determine the extent of radioactive decay, which can influence treatment outcomes. , Devices that can detect radiation doses in these applications can help verify the accuracy of treatment delivery, thus resulting in enhanced quality control and safety. Considering the lack of dose-detection devices in interstitial brachytherapy, we formulated the gel nanosensor into a form factor suitable for in vivo dosimetry.…”

Section: Results and Discussionmentioning

confidence: 99%

“…For instance, 192 Ir, which has a half-life of 74 days, requires monitoring before and during the time of the implant to determine the extent of radioactive decay, which can influence treatment outcomes. 29,30 Devices that can detect radiation doses in these applications can help verify the accuracy of treatment delivery, thus resulting in enhanced quality control and safety. Considering the lack of dosedetection devices in interstitial brachytherapy, we formulated the gel nanosensor into a form factor suitable for in vivo dosimetry.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors

Pushpavanam

Dutta

Inamdar

et al. 2022

ACS Appl. Mater. Interfaces

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Modern radiation therapy workflow involves complex processes intended to maximize the radiation dose delivered to tumors while simultaneously minimizing excess radiation to normal tissues. Safe and accurate delivery of radiation doses is critical to the successful execution of these treatment plans and effective treatment outcomes. Given extensive differences in existing dosimeters, the choice of devices and technologies for detecting biologically relevant doses of radiation has to be made judiciously, taking into account anatomical considerations and modality of treatment (invasive, e.g., interstitial brachytherapy vs noninvasive, e.g., external-beam therapy radiotherapy). Rapid advances in versatile radiation delivery technologies necessitate new detection platforms and devices that are readily adaptable into a multitude of form factors in order to ensure precision and safety in dose delivery. Here, we demonstrate the adaptability of radiation-responsive gel nanosensors as a platform technology for detecting ionizing radiation using three different form factors with an eye toward versatile use in the clinic. In this approach, ionizing radiation results in the reduction of monovalent gold salts leading to the formation of gold nanoparticles within gels formulated in different morphologies including one-dimensional (1D) needles for interstitial brachytherapy, two-dimensional (2D) area inserts for skin brachytherapy, and three-dimensional (3D) volumetric dose distribution in tissue phantoms. The formation of gold nanoparticles can be detected using distinct but complementary modes of readout including optical (visual) and photothermal detection, which further enhances the versatility of this approach. A linear response in the readout was seen as a function of radiation dose, which enabled straightforward calibration of each of these devices for predicting unknown doses of therapeutic relevance. Taken together, these results indicate that the gel nanosensor technology can be used to detect ionizing radiation in different morphologies and using different detection methods for application in treatment planning, delivery, and verification in radiotherapy and in trauma care.

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Section: Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors

Pushpavanam

Dutta

Inamdar

et al. 2022

ACS Appl. Mater. Interfaces

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“…At present, the availability of calibration services for Ir-192 brachytherapy sources at the Primary Standard Dosimetry Laboratory (PSDL) level was available at several National Metrology Institute (NMI's) [13,14], but for Co-60 source brachytherapy only available at German NMI, Physikalisch-Technische Bundesanstalt (PTB) [15].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of Radiation Quality Correction Factor (Kq) Determination for Well-Type Ionization Chamber

Firmansyah

Wulandari³

et al. 2020

SPEKTRA

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This paper deals with the determination of the radiation quality correction factor (kQ) well-type ionization chamber for the measurement of Co-60 brachytherapy. The measurement of the brachytherapy source has been done in the hospital brachytherapy facilities. The measurement of air Kerma has been done using three different ionization chambers 0.6 cm3, 30 cm3, 80 cm3, which have calibration factor traceability for Co-60 and one well-type ionization chamber which calibrated for Ir-192. The determination of the radiation quality correction factor (kQ) was determined based on the results of the air Kerma ratio between measurements using ionization chambers, which have traceability to Co-60 and Ir-192 sources. The results of the measurement of the reference air Kerma rate (RAKR) obtained from the three chambers were 21.36, 19.87, 19.34 mGy.m2.h-1, while the results of measurements with ionization chambers get a value of 19.01 mGy.m2.h-1. The kQCal results from 0.6 cm3 ionization chamber get a value of 1.07. The kQCal value was compared with the value of Andreas Schuller’s et al. kQreff of 1.05 and get a deviation of 2.2%. Implementation of the booth kQ value on the results of the RAKR from the HDR1000Plus well-type ionization chamber in the measurement of brachytherapy in two different facilities gets maximal deviation 1.7% with dose value from Treatment Planning System (TPS). The deviation was in the acceptable range of ±5%. Based on this, the use of radiation quality correction factor (kQ) value can be implemented as one method if it does not have the traceability factor calibration of the Co-60 brachytherapy source.

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Implementation of ICRU report 90 to re-evaluate the dosimetry standards in Taiwan

Lin,

Huang,

et al. 2024

Radiation Physics and Chemistry

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Reference air kerma rate calibration system for high dose rate Ir-192 brachytherapy sources in Taiwan

Cited by 3 publications

References 3 publications

Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors

Versatile Detection and Monitoring of Ionizing Radiation Treatment Using Radiation-Responsive Gel Nanosensors

A Preliminary Study of Radiation Quality Correction Factor (Kq) Determination for Well-Type Ionization Chamber

Implementation of ICRU report 90 to re-evaluate the dosimetry standards in Taiwan

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