Reevaluation of the Risk of Fetal Death and Malformation After Q Fever

Million, Matthieu; Roblot, F.; Carles, Dominiques; D'Amato, Felicetta; Protopopescu, Camélia; Carrieri, Patrizia; Raoult, Didier

doi:10.1093/cid/ciu259

Cited by 37 publications

(29 citation statements)

References 9 publications

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“…33,34 A recently published study in Denmark 35 and a study that we published recently collecting all the data available in the literature in a meta-analysis 36 confirm that Q fever occurring during pregnancy is associated with a risk of miscarriage. The risk of miscarriage is highest in the first trimester, with a risk of fetal growth retardation, fetal malformations and prematurity occurring later.…”

Section: Q Fever During Pregnancymentioning

confidence: 87%

Recent advances in the study of Q fever epidemiology, diagnosis and management

Million

Raoult

2015

Journal of Infection

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110

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Section: Q Fever During Pregnancymentioning

confidence: 87%

Recent advances in the study of Q fever epidemiology, diagnosis and management

Million

Raoult

2015

Journal of Infection

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110

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“…Une autre étude au Danemark suggère qu'il n'y aurait pas d'augmentation des risques de complications obstétricales chez les femmes ayant été exposées à C. burnetii (Nielsen et al 2014). Dernièrement, Million et collaborateurs ont revu les données présentes dans la littérature et déduit des augmentations de mort-nés et malformations après une infection par la fièvre Q durant la grossesse (Million et al 2014). L'effet de l'exposition à C. burnetii durant la grossesse sur les risques de complications obstétricales reste donc un sujet à clarifier.…”

Section: Pathogénieunclassified

Coxiella burnetii, agent de la fièvre Q

Boarbi¹,

Frétin²,

Mori³

2016

Can. J. Microbiol.

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Résumé : La fièvre Q est une zoonose de répartition mondiale excepté la Nouvelle-Zélande. Elle est due à une bactérie intracellulaire : Coxiella burnetii. Cette infection passe souvent inaperçue car la manifestation principale de la forme aiguë de la maladie est un syndrome pseudogrippal spontanément résolutif. C'est l'épidémie qui a eu lieu aux Pays-Bas qui a attiré l'attention sur cette maladie qui était moins étudiée auparavant. Cette synthèse résume la description de la bactérie (taxonomie, cycle intracellulaire et génomique) mais également la maladie (description, diagnostic, pathogénie et épidémiologie). Enfin, la vaccination de l'humain et des animaux est également analysée. Mots-clés : Coxiella burnetii, fièvre Q, épidémiologie, description, génomique.Abstract: Q fever is a zoonosis of worldwide distribution with the exception of New Zealand. It is caused by an intracellular bacterium, Coxiella burnetii. The disease often goes underdiagnosed because the main manifestation of its acute form is a general self-limiting flu-like syndrome. The Dutch epidemics renewed attention to this disease, which was less considered before. This review summarizes the description of C. burnetii (taxonomy, intracellular cycle, and genome) and Q fever disease (description, diagnosis, epidemiology, and pathogenesis). Finally, vaccination in humans and animals is also considered.

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“…Lactation is discouraged due to the excretion of both bacteria and doxycycline through breast milk. 3,14,34 Outcome Acute Q fever typically has a mild course: 60% of the patients have an asymptomatic course, 2-5% need hospitalisation (increasing in case of epidemics) and mortality is 1-2%. Half of the acute Q fever patients in our series received outpatient treatment.…”

Section: Treatmentmentioning

confidence: 99%