Q fever: a contemporary case series from a Belgian hospital

Vanderbeke, Lore; Peetermans, Willy; Saegeman, Veroniek; Munter, Paul De

doi:10.1080/17843286.2016.1165397

Cited by 5 publications

(5 citation statements)

References 42 publications

(69 reference statements)

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“…An immunofluorescence assay is used for the serodiagnosis of Q fever which is the reference method. Thus, acute Q fever diagnosis was made serologically and based on C. burnetii immunofluorescent antibody (IFA) phase 2 IgM positivity (IgM≥ 1/64) and/or concurrent IgM and IgG positivity in a single sample and/or four-fold increase in phase 2 IFA IgG titers in repeat sample obtained at least two weeks later (13). Consistent with this knowledge, we made the diagnosis of Q fever according to above mentioned criteria.…”

Section: Methodsmentioning

confidence: 86%

Are we aware of Q fever enough? experience from a single centre.

Gözdaş¹,

Sırmatel²,

Karabörk³

et al. 2019

Kocaeli Med J

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ÖZ GİRİŞ: Q ateşi, Coxiella burnetii'nin neden olduğu bir zoonozdur. Başlıca klinik prezentasyonları pnömoni ve hepatit'tir. Bununla birlikte, birçok farklı klinik prezentasyonlar nedeniyle Q ateşini tanımak güç olabilir. Bu çalışmada, kurumumuzdaki Q ateşi olgularının klinik ve laboratuvar özelliklerini sunarak Q ateşi farkındalığını artırmayı amaçladık. GEREÇ ve YÖNTEMLER: Hastanemiz veri tabanındaki Q ateşi tanılı hastalar retrospektif olarak değerlendirilmiştir. Hastaların karakteristikleri, başvurudaki klinik ve laboratuvar değerleri kaydedilmiştir. BULGULAR: Bu çalışmaya toplam altı hasta dahil edilmiştir. En sık ateş, iştahsızlık ve bitkinlik gibi semptomlar olmak üzere çeşitli klinik prezentasyonlar gözlenmiştir. En sık laboratuvar anormalliği tüm hastalarda saptanan CRP yüksekliğiydi, LDH ve transaminaz yüksekliği bunu takip etmekteydi. Gerek LDH yüksekliği gerekse transaminaz yüksekliği dört hastada mevcuttu. SONUÇ: Q ateşini teşhis etmek için kullanılan serolojik yöntemler rutin olarak uygulanmamaktadır, bu yüzden Q ateşi olguları kolayca gözden kaçabilir. Biz inanıyoruz ki, endemik bölgelerde nonspesifik antibiyotik tedavisine yeterli yanıt vermeyen hastalarda Q ateşi daha çok araştırılmalıdır. Anahtar kelimeler: Coxiella burnetii, Q ateşi, TürkiyeABSTRACT BACKGROUND: Q fever is a zoonosis caused by Coxiella burnetii. The main clinical presentations are pneumonia and hepatitis. However, it can be difficult to recognise Q fever due to many different clinical presentations. In this study, we aimed to increase the awareness of Q fever by presenting clinical and laboratory features of Q fever cases from our institution. MATERIALS and METHODS:Patients with a diagnosis of Q fever in our hospital database were evaluated retrospectively. Patient characteristics as well as clinical and laboratory values at presentation were recorded. RESULTS:A total of six patients were included in this study. Various clinical presentation was observed such as fever, anorexia and malaise as the most common symptoms. The most common laboratory abnormality was CRP elevation as being detected in all patients followed by LDH and transaminase elevations. both were found in four patients. CONCLUSION:Serological methods used to diagnose Q fever are not routinely performed, so Q fever cases can be missed easily. We believe that Q fever should be investigated further in patients from endemic regions who did not give adequate response to nonspesific antibiotic treatment.

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Section: Methodsmentioning

confidence: 86%

Are we aware of Q fever enough? experience from a single centre.

Gözdaş¹,

Sırmatel²,

Karabörk³

et al. 2019

Kocaeli Med J

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“…More anecdotally, other chronic infections have rarely been associated with secondary amyloidosis, such as Q fever 50,51 and brucellosis 52,53 …”

Section: Infections Associated With Aa Amyloidosismentioning

confidence: 99%

Infections and AA amyloidosis: An overview

et al. 2021

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Background Amyloidoses are a heterogeneous group of systemic diseases characterised by extracellular accumulation of insoluble amyloid fibrils derived from unfolded proteins. Inflammatory (AA) amyloidosis can complicate various inflammatory disorders that are associated with a sustained acute phase response and serum amyloid A (SAA) protein overproduction. Chronic infections were the first recognised cause of amyloidoses. However, with the better management of underlying diseases, the frequency of AA amyloidosis is decreasing. Purpose The aim of this overview was to discuss the several infections associated with AA amyloidosis and the relative frequency of infections as aetiological factors. Methods A search of the literature was performed using the PubMed database using the MeSH terms “Amyloidosis” and “Infections,” from inception to December 31st, 2019. Articles written in other languages than English or French were excluded. Results The frequency of AA amyloidosis secondary to infections decreased from more than 50% to less than 20% after the 2000s, with a parallel increase in the frequency of AA amyloidosis secondary to inflammatory diseases and to an unknown cause. Conclusion Whereas new antibiotics have been developed and sanitary conditions are better, infections still represent 5%‐30% of the causes of AA amyloidosis, including in developed countries. These data argue for better screening of chronic infections to prevent AA amyloidosis and the development of new strategies to manage recurrent infections.

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“…Acute clinical cases manifest flu‐like non‐specific symptoms such as persistent fever (>14 days), pneumonia, myalgia, and headache with occasional abdominal pain and absence of diarrhoea (Graves and Islam, 2016; Njeru et al ., 2016a). Endocarditis and hepatitis are also seen in some acute cases (Vanderbeke et al ., 2016).…”

Section: Clinical Signsmentioning

confidence: 99%

“…Infection due to C. burnetii usually remains asymptomatic in non‐pregnant animals. However, abortion or stillbirth is reported in advanced pregnancy (Van den Brom et al ., 2016). The pathogen has also been associated with infertility and repeat breeding, which may be due to persistent infection in the uterus resulting in chronic endometritis with fibrosis of perivascular and periglandular tissues (Kreizinger et al ., 2015; de Biase et al ., 2018).…”

Section: Clinical Signsmentioning

confidence: 99%

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Current perspectives on the occurrence of Q fever: highlighting the need for systematic surveillance for a neglected zoonotic disease in Indian subcontinent

Sahu

Rawool

Dhaka

et al. 2020

Environ Microbiol Rep

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Summary Coxiellosis or Q fever is an important global occupational zoonotic disease caused by one of the most contagious bacterial pathogens – Coxiella burnetii, which ranks one among the 13 global priority zoonoses. The detection of C. burnetii infection is exhibiting an increasing trend in high‐risk personnel around the globe. It has increasingly been detected from foods of animal origin (including bulk milk, eggs, and meat) as well as tick vectors in many parts of the world. Coxiellosis is reported to be an important public health threat causing spontaneous abortions in humans and potential reproductive failure, which would result in production losses among livestock. Further, comprehensive coverage of the reports and trends of Q fever in developing countries, where this infection is supposed to be widely prevalent appears scarce. Also, the pathogen remains grossly neglected and underreported. Moreover, policymakers and funding agencies do not view it as a priority problem, especially in the Indian subcontinent, including Sri Lanka, Bhutan, Pakistan, Nepal, Bangladesh and Maldives. Here, we review the occurrence and epidemiology of the disease in a global context with special emphasis on its status in the Indian subcontinent.

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Q fever: a contemporary case series from a Belgian hospital

Abstract: Q fever is an infectious disease characterised by a variable clinical presentation. Detection requires correct assessment of the clinical picture in combination with a laboratory confirmation. Treatment and follow-up are intended to avoid a negative outcome.

Cited by 5 publications

References 42 publications

Are we aware of Q fever enough? experience from a single centre.

Are we aware of Q fever enough? experience from a single centre.

Infections and AA amyloidosis: An overview

Current perspectives on the occurrence of Q fever: highlighting the need for systematic surveillance for a neglected zoonotic disease in Indian subcontinent

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