Reevaluation of the deafferentation pain syndrome

Mazars, G; Choppy, M.

doi:10.1016/0304-3959(81)90242-6

Cited by 3 publications

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“…Some early quantitative work in neuropathic pain from brachial plexus lesions showed that opioid injection relieved pain in 70% of cases, but naloxone reversal of relief was observed in less than 25%. In postherpetic pain ‘opioids, placebo, and naloxone produced no clear‐cut differences on pain’ (Mazars & Choppy, 1983). Seven of 16 patients with deafferentation pain had no relief with intravenous morphine, seven had partial relief, and two had complete relief (Tasker et al ., 1983).…”

Section: How Important Is Neuropathic Pain In Pain Management?mentioning

confidence: 99%

Neuropathic pain: evidence matters

McQuay

2002

European Journal of Pain

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"He slept less and less; they gave him opium and began to inject morphine. But this did not relieve him. The dull pain he experienced in the half asleep condition at first only relieved him as a change, but then it became as bad, or even more agonizing, than the open pain."--Tolstoy, The Death of Ivan Ilyitch. It comes as a surprise to many pharmacologists that not all pains are relieved by opioids. Those who work in chronic pain are unfortunately only too aware of the problems that such pains can cause. One of the hallmarks of neuropathic pain is poor or incomplete relief with opioids. As with so many things in medicine, there is nothing novel in this realization, as the Tolstoy quotation shows.

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Section: How Important Is Neuropathic Pain In Pain Management?mentioning

confidence: 99%