The termination sites of the dorsolateral (DSTT) and ventral (VSTT) spinothalamic pathways were determined by using anterograde transport of horseradish peroxidase from the lumbar spinal cord in primates. One animal had no spinal cord lesion, while of two other animals, one received a midthoracic dorsolateral funiculus lesion, and the other received a midthoracic ventral quadrant lesion contralateral to the injection. The thalamic label in the animal with no spinal cord lesion was much less than the label in the two animals with spinal lesions. Moreover, in the animals with spinal lesions, HRP-labeled cells were found within the thalamus. Therefore, the remaining six animals received ipsilateral hemisections and bilateral dorsal column lesions, irrespective of the contralateral lesions. The thalamic label in the animals without contralateral lesions were assumed to represent the total spinothalamic input to the diencephalon. In these animals, label was located mainly in suprageniculate and pulvinar oralis, caudal and oral divisions of ventral posterior lateral nucleus, the lateral half of ventral posterior inferior nucleus, and zona incerta, while in the medial thalamus label was primarily in two distinct bands in medial dorsal nucleus and in the posterior dorsal portion of central lateral nucleus. Scattered lighter labeling was found in other thalamic nuclei. The pattern of terminal labeling observed in the ventral posterior lateral region was arranged in patches, while elsewhere in the thalamus a more uniform labeling pattern was observed. The thalamic label in animals with contralateral ventral quadrant lesions represented the terminations of the DSTT, while the label in animals with contralateral dorsolateral funiculus lesions represented VSTT terminations. The labeling pattern was similar between these two groups. However, there were small differences between them. These results indicate that DSTT and VSTT terminations largely overlap and innervate the lateral and medial thalamamus.

Electrical stimulation of the median nerve is a reproducible and effective means of activating multiple somatosensory cortical areas, and fMR imaging can be used to investigate the complex network that exists between these areas.

In six monkeys spinothalamic (STT) cells were retrogradely labeled by injecting 2% wheat germ agglutinin-conjugated horseradish peroxidase into the somatosensory thalamus. Following a 5-day survival period, the animals were perfused and the tissue was removed and processed with the tetramethyl benzidine technique. In all animals there were HRP-labeled STT cells in all segments of the spinal cord. In one old world monkey, the injection included most of the thalamus and resulted in 18.235 estimated total number of STT cells. Of this total, 35% were located in the upper cervical segments (C1-C3), 18% were located in C4-C8, 19% were in the thoracic spinal cord with most found in T1-T3; 6% were in L1-L3, 13% were in L4-L7, and 7% were in the coccygeal segments. Of the total labeled STT cells, 17% were found in the spinal cord ipsilateral to the thalamic injections; 53% of these cells were located in C1-C3 primarily in lamina VIII. The percentage of label found in the contralateral lower cervical region laminae I-III (43-50%), IV-VI (33-48%), and VII-X (8-17%) was similar among three animals with similar thalamic injections. The distributions of the shapes of the labeled STT cells were similar for each lamina between the lower cervical and lower lumbar regions. The mean diameter of the labeled STT cells varied with spinal cord segment and lamina. The lamina I STT cells were the smallest. In the cervical spinal cord, lamina VIII STT cells had the largest diameters, while in the lumbar region laminae IV-VI had the largest STT cells.

Ventral herniation of the thoracic spinal cord is a partially treatable cause of myelopathy, when recognized promptly and treated surgically. Recognizing this infrequent cause of myelopathy prevents misdiagnosis. Delay in diagnosis may impair recovery at a later date.