Abstract:Summary: The effects of intravenous encainide on digoxin-induced atrial ectopic tachycardia (AET) were investigated in the rat using 3-channel simultaneous limblead electrocardiography. Pentobarbital-anesthetized (35 mg/kg, intraperitoneal) adult male rats were given digoxin subcutaneously, 30 mg/kg. After onset of AET, rats received either saline (0.5 ml/kg) or encainide; 0.25,0.5, 1 .O, or 2.0 mg/kg intravenously in repeated doses at 15-min intervals. At all doses, encainide converted digoxininduced AET to v… Show more
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