The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified α-and β-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis-Menten kinetics, and an impressive rate increase of up to 7569 (k cat /k uncat ) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate degrees of catalysis (k cat /k uncat ) of up to 1259