Cardiac glycoside toxicity in small laboratory animals

Weinhouse, Elliott; Kaplanski, Jacob; Danon, Abraham; Nudel, Dov B.

doi:10.1016/0024-3205(89)90459-1

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1992

2011

Publication Types

Select...

Article3

Book1

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In many parts of the world, ingestion of toxic glycosides causes death of humans and livestock. The digitalis (heart glycoside) family includes the potentially toxic digoxin (Figure 1), which is an inhibitor of the Na/K‐ATPase, leading to a positive inotrope effect (i. e. increases heart contraction force) 1. Digoxin is one of the most prescribed of all cardiac drugs, and is used for heart failure and atrial fibrillation.…”

Section: Introductionmentioning

confidence: 99%

Hydrolysis of Toxic Natural Glucosides Catalyzed by Cyclodextrin Dicyanohydrins

2008

View full text Add to dashboard Cite

The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified α-and β-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis-Menten kinetics, and an impressive rate increase of up to 7569 (k cat /k uncat ) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate degrees of catalysis (k cat /k uncat ) of up to 1259

show abstract

Section: Introductionmentioning

confidence: 99%