Reevaluation of Congo Red Test as Reticuloendothelial System Function Test Using Tritiated Congo Red Autoradiography

Ouchi, E; Miura, Kiyomi; Yamagata, Shoichi

doi:10.1620/tjem.109.251

Cited by 3 publications

(4 citation statements)

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“…Hence, it is clear why Japanese investigators explored other properties of CR. Japanese researchers presented data showing that intravenously injected CR was selectively taken up by Kupffer’s cells [144,145]. CR passes mainly through Kupffer’s cells and is later excreted into bile via hepatocytes; it also partially passes through other cells in the reticuloendothelial system [143–145].…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Congo Red and amyloids: history and relationship

et al. 2019

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Staining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo. Analysis of scientific data from previous studies shows that CR staining alone is not sufficient for confirmation of the amyloid nature of protein aggregates in vitro or for diagnosis of amyloidosis in tissue sections. In the present paper, we describe the characteristics and limitations of other methods used for amyloid studies. Our historical review on the use of CR staining for amyloid studies may provide insight into the pitfalls and caveats related to this technique for researchers considering using this dye.

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Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Congo Red and amyloids: history and relationship

et al. 2019

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“…On the contrary, the Congo red test has many advantages because this test can be repeated and applied to the patients without any discomfort or toxicity. We reported previously the histological localization of Congo red injected intravenously (Ouchi et al 1973) and the Congo red clearance (Miura and Ouchi 1974). From these studies, the Congo red test is thought to express mainly Kupifer's cell function and partly the functions of other RES.…”

Section: Discussionmentioning

confidence: 95%

“…We presented in previous papers data on Congo red entering the circulatory system, which indicated that Congo red injected intravenously was taken up almost selectively by Kupffer's cells (Ouchi et al 1973;Miura and Ouchi 1974). Fig.…”

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confidence: 98%

Clinical Significance of Congo Red Test

Ouchi

Nomura

Watabe

et al. 1976

Tohoku J. Exp. Med.

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“…There are a few reticuloendothelial system (RES) function tests which are applicable in clinical medicine (Ouchi et al 1973;Miura and Ouchi 1974). The RES function test using 131I-labeled aggregated human albumin (131IAA) as test particle was primarily reported by Benacerraf et al (1957), and it is thought to be one of the best methods for the study of RES function of human beings.…”

mentioning

confidence: 99%