Clinical Significance of Congo Red Test

Ouchi, E; Nomura, Nobuo; Watabe, Shigeru; Seiji, Kazumasa; Sato, Jyo; Gonai, Toshikatsu; Miura, Kiyomi; Yamagata, Shoichi

doi:10.1620/tjem.118.suppl_191

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…In 1976, Ouchi et al [143] stated that there were no appreciable data on Bennhold’s test for the diagnosis of amyloidosis in scientific Japanese literature. This probably points to the fact that amyloidosis is an extremely rare disease in Japan [143]. Hence, it is clear why Japanese investigators explored other properties of CR.…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

“…Japanese researchers presented data showing that intravenously injected CR was selectively taken up by Kupffer’s cells [144,145]. CR passes mainly through Kupffer’s cells and is later excreted into bile via hepatocytes; it also partially passes through other cells in the reticuloendothelial system [143–145].…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

“…No pathological features specifically influencing the CR index (CRI) were found by Japanese researchers during histological studies. At the same time, it was shown that the CRI is usually higher in liver diseases than in various other diseases [143]. Ouchi et al [143] showed that an increase in the CRI is most visible in cases of liver cirrhosis and can also be explained by an obstructive change in liver blood flow followed by hepatic tissue damage.…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

“…At the same time, it was shown that the CRI is usually higher in liver diseases than in various other diseases [143]. Ouchi et al [143] showed that an increase in the CRI is most visible in cases of liver cirrhosis and can also be explained by an obstructive change in liver blood flow followed by hepatic tissue damage. It should be noted that the authors did not provide any explanation for what CRI represented.…”

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

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Congo Red and amyloids: history and relationship

et al. 2019

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Staining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo. Analysis of scientific data from previous studies shows that CR staining alone is not sufficient for confirmation of the amyloid nature of protein aggregates in vitro or for diagnosis of amyloidosis in tissue sections. In the present paper, we describe the characteristics and limitations of other methods used for amyloid studies. Our historical review on the use of CR staining for amyloid studies may provide insight into the pitfalls and caveats related to this technique for researchers considering using this dye.

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Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

Section: The Use Of Cr In the Study Of Amyloidosismentioning

confidence: 99%

See 2 more Smart Citations

Congo Red and amyloids: history and relationship

et al. 2019

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“…5 The molecular interaction between Congo red and amyloid deposits was briefly utilized clinically as an in vivo test for the presence of systemic amyloid. 10,11 The dye was injected intravenously, and the proportion retained in the serum after a fixed period was estimated. The extent of clearance from the blood was thought to be proportional to the total body amyloid load.…”

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confidence: 99%