Reentrainment of the circadian pacemaker during jet lag: East-west asymmetry and the effects of north-south travel

Diekman, Casey O.; Bose, Amitabha

doi:10.1016/j.jtbi.2017.10.002

Cited by 60 publications

(66 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kronauer and colleagues further modified the van der Pol model to match experimental data on human circadian rhythms (Kronauer, 1990;Forger et al, 1999). Variants of the Kronauer model are still being used to explain properties of jet-lag and to design optimal schedules for fast re-entrainment following transmeridian travel (Serkh & Forger, 2014;Diekman & Bose, 2017). The process of re-entrainment has also been studied in more detailed models of the SCN network (Kingsbury et al, 2016), and hierarchical systems with internal desynchrony between the SCN and clocks in peripheral organs (Leise & Siegelmann, 2006).…”

Section: Modelling Section 2: Mathematical Modelling Of Circadian Entmentioning

confidence: 99%

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

Belle

Diekman

2018

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands, from slow delta waves (0.1 Hz) to ultra-fast ripples (600 Hz). Here, we focus on ultra-slow neuronal oscillators in the hypothalamic suprachiasmatic nuclei (SCN), the master daily clock that operates on interlocking transcription-translation feedback loops to produce circadian rhythms in clock gene expression with a period of near 24 h (< 0.001 Hz). This intracellular molecular clock interacts with the cell's membrane through poorly understood mechanisms to drive the daily pattern in the electrical excitability of SCN neurons, exhibiting an up-state during the day and a down-state at night. In turn, the membrane activity feeds back to regulate the oscillatory activity of clock gene programs. In this review, we emphasise the circadian processes that drive daily electrical oscillations in SCN neurons, and highlight how mathematical modelling contributes to our increasing understanding of circadian rhythm generation, synchronisation and communication within this hypothalamic region and across other brain circuits.

show abstract

Section: Modelling Section 2: Mathematical Modelling Of Circadian Entmentioning

confidence: 99%

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

Belle

Diekman

2018

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mais le sommeil dépend aussi de l'activité de l'horloge biologique et ses synchronisateurs. Une exposition à la lumière le soir (par exemple par les écrans) a tendance à décaler l'horloge, surtout si l'exposition à la lumière pendant la journée est à basse intensité [5,6] L'horloge biologique réagit moins vite que le système homéostatique : un décalage horaire de plusieurs fuseaux horaires ne sera rattrapé qu'en plusieurs jours [7]. Pendant une période de confinement prolongée, une diminution de l'exposition à la lumière du jour pendant la journée, une augmentation de l'utilisation des écrans (pour le travail ou pour se distraire) le soir et la perte des routines habituelles peuvent interférer avec l'horloge biologique avec un affaiblissement, voire une désynchronisation des rythmes circadiens [8].…”

Section: Introductionunclassified

Les effets de confinement SARS-CoV-2 sur le sommeil : enquête en ligne au cours de la quatrième semaine de confinement

Hartley

Francs²,

Aussert

et al. 2020

L'Encéphale

View full text Add to dashboard Cite

Mots clés : Sommeil Confinement COVID 19 « Jet-lag » social Habitudes de sommeil r é s u m é Objectif.-Déterminer l'évolution du sommeil chez les Franç ais pendant le confinement motivé par la pandémie du SARS-CoV-2 et définir les facteurs comportementaux associés à un sommeil détérioré. Méthodologie.-Une enquête en ligne via les réseaux sociaux pendant la période de confinement. Les questions ont ciblé les conditions de confinement, les comportements relatifs au sommeil et les éléments de l'environnement potentiellement perturbateurs du sommeil (exposition à la lumière et activités sportives). Résultats.-Au total, 1777 participants ont été inclus dont 77 % femmes, 72 % âgés de 25-54 ans. Les conditions de confinement les plus fréquentes étaient en couple avec enfants (36 %) et en maison avec jardin (51 %). Quarante-sept pour cent rapportent une diminution de la qualité du sommeil en confinement. Les facteurs associés à une détérioration du sommeil retenus par l'analyse multivariée sont une diminution de la durée du sommeil (OR 15,52-p < 0,001), un coucher plus tardif (OR 1,72-p < 0,001), un lever plus matinal (2,18-p = 0,01), des horaires plus irréguliers (OR 2,29-p < 0,001), une diminution de l'exposition à la lumière du jour (OR 1,46-p = 0,01) et une augmentation de l'utilisation des écrans le soir (OR 1,33-p = 0,04). Conclusion.-La mauvaise qualité subjective du sommeil en confinement est associée à une modification des comportements relatifs au sommeil et de l'exposition à la lumière (moins de lumière du jour et plus d'écran le soir). Pour optimiser le sommeil en confinement, des horaires adaptés et réguliers, une exposition de plus d'une heure/jour à la lumière du jour et l'éviction des écrans le soir sont à conseiller.

show abstract

“…For instance, when a single daily 25 mpk dose is given at ZT8, the PF‐670‐induced phase delay is balanced with the light‐induced phase advance, and reaches the equilibrium point after 1 week of dosing (Fig F) (Kim et al , ). At this point, with a weaker attenuating effect of light in model N, the constant stable phase delay induced by PF‐670 is larger than in model W. Furthermore, when a higher dose is used, the effect of CK1i under LD differs qualitatively depending on individual photosensitivity: The PF‐670‐induced phase delay overcomes the light‐induced phase advance, and thus, it accumulates in model N while the phase shift unstably alternates between delay and advance in model W due to amplitude suppression (Fig EV4D–G) (Diekman & Bose, ). Thus, the degree of photosensitivity of the individual likely has dramatic consequences for the effect of clock‐modulating drugs.…”

Section: Resultsmentioning

confidence: 99%

“…Due to this synergistic effect between light and PF‐670, the level of PER1/2 protein in model W greatly increases (nighttime at day 3; F) compared with model N, which leads to a strong repression of the transcription for clock genes such as Cry1 mRNA and thus the amplitude suppression at day 3 unlike in model N (day 3; G). This amplitude suppression causes the circadian rhythms to reach a singular point (Diekman & Bose, ) and thus leads to an alternating phase shift (D). The vehicle in (G) represents a mean of relative Cry1 mRNA abundances simulated with models N and W.…”

Section: Resultsmentioning

confidence: 99%

Systems approach reveals photosensitivity and PER 2 level as determinants of clock‐modulator efficacy

Kim

Chang

Chen

et al. 2019

Molecular Systems Biology

View full text Add to dashboard Cite

In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day–night cycle. Failure of synchrony, which increases the risk for numerous chronic diseases, can be treated by phase adjustment of the circadian clock pharmacologically, for example, with melatonin, or a CK 1δ/ε inhibitor. Here, using in silico experiments with a systems pharmacology model describing molecular interactions, and pharmacokinetic and behavioral experiments in cynomolgus monkeys, we find that the circadian phase delay caused by CK 1δ/ε inhibition is more strongly attenuated by light in diurnal monkeys and humans than in nocturnal mice, which are common preclinical models. Furthermore, the effect of CK 1δ/ε inhibition strongly depends on endogenous PER 2 protein levels, which differs depending on both the molecular cause of the circadian disruption and the patient's lighting environment. To circumvent such large interindividual variations, we developed an adaptive chronotherapeutics to identify precise dosing regimens that could restore normal circadian phase under different conditions. Our results reveal the importance of photosensitivity in the clinical efficacy of clock‐modulating drugs, and enable precision medicine for circadian disruption.

show abstract

Reentrainment of the circadian pacemaker during jet lag: East-west asymmetry and the effects of north-south travel

Cited by 60 publications

References 53 publications

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

Les effets de confinement SARS-CoV-2 sur le sommeil : enquête en ligne au cours de la quatrième semaine de confinement

Systems approach reveals photosensitivity and PER 2 level as determinants of clock‐modulator efficacy

Contact Info

Product

Resources

About