Reductive thiolation and oxidative dehydroaromatization of cyclohexanones with primary amines and sodium sulfinates to access o-sulfanylanilines

Abstract

HI-promoted cascade reactions of cyclohexanones with primary amines and sodium sulfinates are described, which provides an unprecedented method to access o-sulfanylanilines using cyclohexanones as an aryl source and sodium sulfinates...

Deep eutectic solvents as sustainable media for multicomponent sulfonylation: an efficient strategy to synthesize (hetero)aryl sulfones

“…Another widely used strategy to synthesize sulfones is the coupling reaction of sulfinates. 22–29 All these protocols are based on organic sulfur-containing reagents, which are often difficult to prepare and therefore of limited availability. For this reason, new methodologies that avoid the use of unstable and toxic reagents, and harsh reaction conditions are in high demand.…”

Diazotization-Enabled Deaminative Late-Stage Functionalization of Primary Sulfonamides

“…Primary sulfonamides are prevalent in bioactive molecules, especially in pharmaceuticals, and have become a privileged fragment in drug discovery . Late-stage functionalization of sulfonamides mainly relies on N -terminal substitutions . Direct derivatization of sulfonamide-based drugs will represent a facile and powerful strategy for accelerating drug innovation.…”