Reductive cleavage of CC bonds as a new strategy for turn-on dual fluorescence in effective sensing of H<sub>2</sub>S

Wang, Chunfei; Cheng, Xiaoxiang; Tan, Jiajia; Ding, Zhaoyang; Wang, Wenjing; Yuan, Daqiang; Li, Gang; Zhang, Hongjie; Zhang, Xuanjun

doi:10.1039/c8sc03430c

Cited by 37 publications

(21 citation statements)

References 30 publications

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“…ity and response time of detection, fluorescent probes with superior advantages for monitoring H 2 S in real time have been widely investigated. [337][338][339][340][341][342][343][344][345][346][347][348][349][350] However, the applications for in vivo H 2 S detection are severely limited because of the low tissue penetration and spatial resolution, as well as the poor photostability. Thus, other advanced imaging techniques for superior H 2 S detection have been developed, such as NIR-I/II, PA, MR, and PET imaging, allowing for early detection and diagnosis of diseases, realtime observation of biological processes during targeted delivery, cellular uptake, and biodistribution of therapeutics in a detailed manner (Table 3).…”

Section: Bioimagingmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.

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Section: Bioimagingmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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“…Fluorescent probes for H 2 S using a C=C bond. Wang and colleagues (25) reported a new design strategy to detect H 2 S (Fig. 3E).…”

Section: Recent Developments In Fluorescent Probes For H 2 Smentioning

confidence: 99%

Recent advances in probe design to detect reactive sulfur species and in the chemical reactions employed for fluorescence switching

Echizen

Hanaoka

2021

J. Clin. Biochem. Nutr.

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Reactive sulfur species, including hydrogen sulfide, hydropersulfide, and polysulfide, have many roles in biological systems. For example, hydrogen sulfide is involved in the relaxation of vascular smooth muscles and mediation of neurotransmission, while sulfane sulfur, which exists in cysteine persulfide/polysulfide, and glutathione persulfide/polysulfide, is involved in physiological antioxidation and cytoprotection mechanisms. Fluorescence imaging is well suited for real-time monitoring of reactive sulfur species in living cells, and many fluorescent probes for reactive sulfur species have been reported. In such probes, the choice of detection chemistry is extremely important, not only to achieve effective fluorescence switching and high selectivity, but also because the reactions may be applicable to develop other chemical tools, such as reactive sulfur species donors/scavengers. Here, we present an overview of both widely used and recently developed fluorescent probes for reactive sulfur species, focusing especially on the chemical reactions employed in them for fluorescence switching. We also briefly introduce some applications of fluorescent probes for hydrogen sulfide and sulfane sulfur.

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“…Reliable bioanalytical methods for highly specific and sensitive detection of H2S is key for investigation of H2S functions in biological systems [6]. Over the past few decades, several techniques have been reported for H2S detection in bulk solution [9][10][11][12][13][14]. Of various approaches, optical detection using H2S responsive sensors has been recognized as one of the most promising technology due to its inherent advantages, such as high sensitivity and simplicity, rapidity, and efficiency [15,16].…”

Section: Introductionmentioning

confidence: 99%

Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells

Liu

Duan

Zhang

et al. 2020

Analytica Chimica Acta

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Gasotransmitter hydrogen sulfide (H2S), produced enzymatically in body, has important functions in biological signaling and metabolic processes. An abnormal level of H2S expression is associated with different diseases, therefore, development of novel bioanalytical methods for rapid and effective detection of H2S in biological conditions is of great importance. In this work, we report the development of a new responsive nanosensor for ratiometric luminescence detection of H2S in aqueous solution and live cells. The nanosensor (Ru@FITC-MSN) was prepared by immobilizing a luminescent ruthenium(II) (Ru(II)) complex into a fluorescein isothiocyanate (FITC) conjugated water-dispersible mesoporous silica nanoparticle (MSN), showing dual emission bands at 520 nm (FITC) and 600 nm (Ru complex). The red luminescence of the formed Ru@FITC-MSN was quenched in the presence of Cu 2+ . The in-situ generated Ru-Cu@FITC-MSN responded to H2S rapidly and selectively, showing a linear ratiometric luminescence change in FITC and Ru(II) channels with the H2S concentration (0.5-4 M). Limit of detection (LoD) and limit of quantification (LoQ) were determined to be 0.36 and 1.21 M. Followed by investigation of cellular uptake processes, the utility of the nanosensor for ratiometric imaging of H2S in live cells and its capability to monitor H2S levels in inflammatory breast cancer cells were then demonstrated. This study provides a powerful approach for detection of highly reactive and unstable H2S biomolecules in live systems.

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Reductive cleavage of CC bonds as a new strategy for turn-on dual fluorescence in effective sensing of H₂S

Abstract: Four effective probes with turn-off to turn-on fluorescence switches were successfully applied for sensing H2S.

Cited by 37 publications

References 30 publications

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Recent advances in probe design to detect reactive sulfur species and in the chemical reactions employed for fluorescence switching

Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells

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Reductive cleavage of CC bonds as a new strategy for turn-on dual fluorescence in effective sensing of H2S

Abstract: Four effective probes with turn-off to turn-on fluorescence switches were successfully applied for sensing H2S.

Cited by 37 publications

References 30 publications

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Recent advances in probe design to detect reactive sulfur species and in the chemical reactions employed for fluorescence switching

Responsive nanosensor for ratiometric luminescence detection of hydrogen sulfide in inflammatory cancer cells

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About

Reductive cleavage of CC bonds as a new strategy for turn-on dual fluorescence in effective sensing of H₂S