Reduction/temperature/pH multi-stimuli responsive core cross-linked polypeptide hybrid micelles for triggered and intracellular drug release

Qu, Jing; Wang, Qiuyue; Chen, Kanglong; Luo, Jianbin; Zhou, Qing‐han; Lin, Jianwei

doi:10.1016/j.colsurfb.2018.06.015

Cited by 41 publications

(14 citation statements)

References 26 publications

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“…The stimuli-responsive drug release systems, which would be degraded by responding with the exogenous physicochemical stimulus (pH, reducing agent, light, temperature, etc. ) in tumor microenvironment, garnered considerable attention during the last decade (El-Sawy et al, 2018;Jiménez-Balsa et al, 2018;Li et al, 2018;Qu et al, 2018). Among numerous design, disulfide linkages were widely utilized to fabricate responsive systems due to the dramatical difference of the reducing glutathione (GSH) concentration between extracellular and intracellular microenvironment (ca.…”

Section: Introductionmentioning

confidence: 99%

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy

2020

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Section: Introductionmentioning

confidence: 99%

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy

2020

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“…Generally, these stimuli can be classified into two primary categories: internal and external [143]. Internal stimuli depend on the various physicochemical situations available at the target site, including differences in the pH, temperature, redox potential, hypoxia, and enzyme concentrations between normal and diseased cells [144][145][146]. External stimuli can attain the optimal spatio-temporal control of the drug release.…”

Section: Stimuli-responsive Therapeutic Platform Based On Mofsmentioning

confidence: 99%

Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

2022

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Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

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“…Nanotherapeutics with multi-responsive can achieve spatial and temporal release of drugs in diseased tissues (Qu et al, 2018 ). Kaplan group was the first to report that SFNPs showed an obvious pH-dependent drug release property.…”

Section: Multi-stimuli-responsive Of Sfnpsmentioning

confidence: 99%

Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery

Canup

Tong

et al. 2020

Front. Chem.

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Silk fibroin has the merits of biocompatibility, biodegradability, ease of processing, and feasibility of modification, which present it as a promising drug delivery material. This review focuses on the structures of silk fibroin, the controlled transformation of secondary structures, and the formation mechanism of silk fibroin-based nanoparticles (SFNPs). We also discuss the intrinsic multi-responsive, surface functionalization, and transgenic modification of SFNPs for drug delivery.

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Reduction/temperature/pH multi-stimuli responsive core cross-linked polypeptide hybrid micelles for triggered and intracellular drug release

Cited by 41 publications

References 26 publications

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy

Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery

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