Reduction-responsive Au decorated mesoporous silica-based nanoplatform for photodynamic-chemotherapy

Guo, Dongxue; Bao, Yanli; Yang, Huailin; Chen, Li

doi:10.1016/j.micromeso.2019.109729

Cited by 11 publications

(7 citation statements)

References 41 publications

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“…Guo and his colleagues 106 designed a novel nanoplatform to effectively combine photodynamic therapy and chemotherapy. The prepared nanoplatform contained mesoporous silica nanoparticles (MSNs) as the nanocarrier, Au nanoparticles on the surface of MSNs as the photosensitizer, thiol-modified polyethylene glycol (mPEG-SH) coated on the nanostructure via Au–S bonds as the reduction-responsive gate-keeper and drug doxorubicin, which was loaded into MSN-Au-PEG via pore adsorption (Fig.…”

Section: Plasmonic/ceramic Nanoparticle Hybridsmentioning

confidence: 99%

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

et al. 2023

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Section: Plasmonic/ceramic Nanoparticle Hybridsmentioning

confidence: 99%

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

et al. 2023

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“…According to the diffraction pattern of Fig. 1, three distinct characteristic peaks at 2.2°, 3.9°, 4.6° and a mild peak at 6.1° are observed for MSNs which are attributed to the re ections 100, 110, 200 and 210 planes of the hexagonal ordering [35]. TEM imaging was also used to depict the mesoporous structure of MSNs.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Keshavarz

Nasab

Mozafari

2023

Preprint

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Mesoporous silica nanoparticles (MSNs) have received particular attention in drug delivery applications during recent years. In this study, we successfully synthesized MCM-41 MSNs by sol-gel method. Chitosan polymer as a pH-sensitive capping was coated on MSNs by (3-Glycidyloxypropyl)trimethoxysilane (GPTMS) crosslinker and quercetin (Que) as a compound with anticancer properties was loaded into prepared nanoparticles (Que@Cs-MSNs) for the first time. The structural characteristics and physicochemical properties were investigated by small-angle X-ray diffraction (SAXS), Nitrogen adsorption-desorption, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM) and Fourier transform infrared (FTIR) methods. Accordingly, the pore size of the hexagonal silica structure was found to be about 3.5 nm, and the dimensions of the Que@Cs-MSNs were calculated to be about 185 nm. The release behavior and release kinetics were studied at pH of 5 and 7.4 and the results showed that the presence of the chitosan coating due to its pH-sensitive nature, in addition to affecting the release rate, caused a change in the release kinetics due to swelling in acidic pH. Also, the results of the cytotoxicity test using MTT assay demonstrated that Que@Cs-MSNs show a higher anticancer effect compared to free Que against G-292 osteosarcoma cancer cells after 72 hours of incubation.

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“…The results showed an enhancement in the X-ray attenuation efficiency compared to other metal NPs [ 256 ]. Many other examples are found in the literature, where MSNPs represent a template for the assembly of multifunctional nanoclusters for cancer therapy [ 257 , 258 , 259 , 260 ].…”

Section: Nano-based Building Blocksmentioning

confidence: 99%

Nanocluster-Based Drug Delivery and Theranostic Systems: Towards Cancer Therapy

2022

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Over the last decades, the global life expectancy of the population has increased, and so, consequently, has the risk of cancer development. Despite the improvement in cancer therapies (e.g., drug delivery systems (DDS) and theranostics), in many cases recurrence continues to be a challenging issue. In this matter, the development of nanotechnology has led to an array of possibilities for cancer treatment. One of the most promising therapies focuses on the assembly of hierarchical structures in the form of nanoclusters, as this approach involves preparing individual building blocks while avoiding handling toxic chemicals in the presence of biomolecules. This review aims at presenting an overview of the major advances made in developing nanoclusters based on polymeric nanoparticles (PNPs) and/or inorganic NPs. The preparation methods and the features of the NPs used in the construction of the nanoclusters were described. Afterwards, the design, fabrication and properties of the two main classes of nanoclusters, namely noble-metal nanoclusters and hybrid (i.e., hetero) nanoclusters and their mode of action in cancer therapy, were summarized.

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Reduction-responsive Au decorated mesoporous silica-based nanoplatform for photodynamic-chemotherapy

Cited by 11 publications

References 41 publications

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

Chitosan capped MSNs as a carrier of quercetin: Preparation, release kinetic study and cytotoxicity assay on osteosarcoma cancer cell line

Nanocluster-Based Drug Delivery and Theranostic Systems: Towards Cancer Therapy

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