“…These regression models adjusted for body mass index (BMI), mean arterial pressure, heart rate, sex, age, race, connective tissue disease not listed as exclusion criteria, diabetes, use of blood thinning or blood pressure medication, and smoking history (ever/never). Diabetes17 and cigarette smoking16 may contribute to reduced nailfold capillary blood speed, while osteoarthritis may involve morphological abnormalities 18. For the rest of the covariates included in the model, no prior study had been conducted to investigate their relation with nailfold capillary blood flow, but we suspected a potential relation a priori and adjusted for them.…”