Reduction of Radiation Damage to the Intestinal Mucous Membrane by Local Hypoxia

Larsson, B.; Sténson, S

doi:10.1038/205364a0

Cited by 12 publications

(3 citation statements)

References 5 publications

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“…Intra-arterial treatment with vasoconstrictive agents in order to protect the intestinal mucosa is difficult to use during fractionated radiotherapy. Previous studies with local application of vasoconstrictive agents on the mucosal surface have also used operative measures and have not been applied in clinical practice (13,14). Local application has been easy to use and allowed irradiation with positioning of the animal.…”

Section: Discussionmentioning

confidence: 99%

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Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

et al. 1995

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Reactions from the rectal mucosa often give rise to troublesome side-effects during and after radiotherapy in the pelvic region. Local vasoconstriction in the rectal mucosa will cause an ischemia which will decrease the sensitivity of the mucosal cells to radiation and thereby these side-effects can be reduced. Triglycyl-lysine-vasopressin applied rectally in 1% Blanose solution gave in the present study significant radioprotection of the rectal mucosa in the doses of 0.8, 1.6, and 3.2 mg. These doses are, however, very high. Triglycyl-lysine-vasopressin in 1.2% Natrosol solution in a dose of 128 micrograms did not show any certain protective effects. However lysine-vasopressin in 1.2% Natrosol solution in a dose of 16 micrograms gave significant radioprotection of the rectal mucosa. This dose level has in a previous study not given any significant effects on the systemic circulation. Lysine-vasopressin in Natrosol solution seems to be a suitable combination for further studies.

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Section: Discussionmentioning

confidence: 99%

“…These can be arterially with good protective effect (10)(11)(12). application of suitable vasoconstrictive agents surface of the intestinal mucosa is a further ility and studies on local application ephrine and sodium sulphite have shown promising sults (13,14).…”

mentioning

confidence: 99%

Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

et al. 1995

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“…Thus, broadly speaking, the majority of investigations during this time appear to reflect the community's understanding of the immediate physicochemical radiation reaction; thus, the overarching target was to reduce the presence and/or impact of free radicals and their role in the initial biological response. Although this led to a somewhat narrow spectrum of agents being assessed, nonetheless, this approach was supplemented by some of the investigators with respect to their growing appreciation that low oxygen levels, whether directly or indirectly induced, also offers a level of normal tissue protection (Davis et al 1958;Larsson & Stenson 1965). However, these latter studies might also speak more to a search for mechanism, rather than a practical means of preventing radiation injury in the field.…”

Section: Kickmentioning

confidence: 99%

Saving normal tissues – a goal for the ages

Groves

Williams

2019

International Journal of Radiation Biology

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Purpose: Almost since the earliest utilization of ionizing radiation, many within the radiation community have worked towards either preventing (i.e. protecting) normal tissues from unwanted radiation injury or rescuing them from the downstream consequences of exposure. However, despite over a century of such investigations, only incremental gains have been made towards this goal and, with certainty, no outright panacea having been found. In celebration of the 60 th anniversary of the International Journal of Radiation Biology and to chronicle the efforts that have been made to date, we undertook a non-rigorous survey of the articles published by normal tissue researchers in this area, using those that have appeared in the aforementioned journal as a road map. Three 'snapshots' of publications on normal tissue countermeasures were taken: the earliest (1959-1963) and most recent (2013-2018) 5-years of issues, as well as a 5-year intermediate span (1987-1991). Conclusions: Limiting the survey solely to articles appearing within International Journal of Radiation Biology likely reduced the number of translational studies interrogated given the basic science tenor of this particular publication. In addition, by taking 'snapshots' rather than considering the entire breadth of the journal's history in this field, important papers that were published during the interim periods were omitted, for which we apologize. Nonetheless, since the journal's inception, we observed that, during the chosen periods, the majority of studies undertaken in the field of normal tissue countermeasures, whether investigating radiation protectants, mitigators or treatments, have focused on agents that interfere with the physical, chemical and/or biological effects known to occur during the acute period following whole body/ high single dose exposures. This relatively narrow approach to the reduction of normal tissue effects, especially those that can take months, if not years, to develop, seems to contradict our growing understanding of the progressive complexities of the microenvironmental disruption that follows the initial radiation injury. Given the analytical tools now at our disposal and the enormous benefits that may be reaped in terms of improving patient outcomes, as well as the potential for

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Dosimetry and Radiobiology of Protons as Applied to Cancer Therapy and Neurosurgery

Larsson

1980

Advances in Radiation Protection and Dosimetry in Medicine

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Reduction of Radiation Damage to the Intestinal Mucous Membrane by Local Hypoxia

Cited by 12 publications

References 5 publications

Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

Radioprotective Effect of Local Administration of Lysine-Vasopressin and Triglycyl-Lysine-Vasopressin on the Rectal Mucosa in Rats

Saving normal tissues – a goal for the ages

Dosimetry and Radiobiology of Protons as Applied to Cancer Therapy and Neurosurgery

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