Reduction of Postischemic Edema with Hyperbaric Oxygen

Nylander, G; Lewis, David H.; Nordström, H.; Larsson, Jörgen

doi:10.1097/00006534-198510000-00021

Cited by 177 publications

(65 citation statements)

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“…Clinical applications of HBO include the treatment of chronic refractory osteomyelitis [5,7] compartment syndromes [20,24], and as an adjunct for healing of problem wounds [18,22]. Staple and Clement [23] recommended the use of HBO following musculoskeletal injuries in conjunction with physiotherapy and exercise.…”

Section: Discussionmentioning

confidence: 99%

Effects of different exposures of hyperbaric oxygen on ligament healing in rats

Ishii

Ushida

Tateishi

et al. 2002

Journal Orthopaedic Research

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Hyperbaric oxygen (HBO) is a method of augmenting, intermittently, oxygen availability to tissues. We examined the effect of three different HBO exposures on the healing of experimentally induced ligament lacerations in the right hind limb of 44 male Wistar rats. Animals were divided into four groups after ligament injury: (a) control group, animals breathed room air a t 1 ATA (atmosphere absolute) in a hyperbaric chamber for 60 min; (b) HBO treatment at 1.5 ATA for 30 rnin once a day, (c) HBO treatment at 2 ATA for 30 min once a day, (d) 2 ATA for 60 rnin once a day. At 14 days post-ligament injury, we compared the ligaments of the four treatment groups for gross appearance, histology and expression of pro-a( I) mRNA by northern hybridization. Our results indicate that HBO was effective in promoting ligament healing compared to control (p < 0.01). Of these three exposures, HBO at 2 ATA for 60 min was the most effective, resulting in enhanced extra-cellular matrix deposition as measured by collagen synthesis.

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Section: Discussionmentioning

confidence: 99%

Effects of different exposures of hyperbaric oxygen on ligament healing in rats

Ishii

Ushida

Tateishi

et al. 2002

Journal Orthopaedic Research

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“…This edema seems to be important in maintaining ischemia, because it compresses the microcirculation and decreases tissue perfusion. When the circulation is restored after long ischemic periods, physiologic shunts are opened, increasing the edema, resulting in a paradoxic ischemia (no-reflow phenomenon) 8 . HBO used early might interfere with this sequence by promoting vessel constriction, decreasing the flow and thus the edema.…”

Section: Discussionmentioning

confidence: 99%

“…HBO used early might interfere with this sequence by promoting vessel constriction, decreasing the flow and thus the edema. Hyperoxygenation would compensate for the decrease of flow, maintaining tissue oxygenation in suitable level 8 . Another possible mechanism of action associated with HBO is the decrease in the neutrophil linkage to the endothelial wall, which minimizes the delivery of free radicals produced by the reperfusion phenomenon 8,9 .…”

Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygen on the regeneration of experimental crush injuries of nerves

et al. 1999

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SUMMARY: Hyperbaric oxygen has been successfully used on treatment of acute ischemic injuries involving soft tissues and chronic injuries. In nerve crush injuries, the mechanisms involved are very similar to those found in ischemic injuries. Consequently, it is logical to hypothesize that hyperbaric oxygen should improve nerve repair, which is a critical step on functional recovery. In the present study, we created standard nerve crush injuries on sciatic nerves of rats, which underwent treatment with hyperbaric oxygen. Results were assessed by functional evaluation using walking-track analysis. The functional recovery indexes observed did not differ from control group. We concluded that hyperbaric oxygen therapy, in the schedule used, had no influence on functional recovery after nerve crush injuries.

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“…H y p e r b a r i c ox y g e n ( H B O ) t h e r a p y h a s b e e n investigated in several experimental and clinical conditions which cannot be treated with currently available medical or surgical options [4,5] . HBO has been shown to have bactericidal activity against anaerobic bacteria [6] .…”

Section: Introductionmentioning

confidence: 99%

Combination of allopurinol and hyperbaric oxygen therapy: A new treatment in experimental acute necrotizing pancreatitis?

Cömert¹,

Işık²,

Aydin³

et al. 2007

WJG

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AIM:To investigate the individual and combined effects of allopurinol and hyperbaric oxygen (HBO) therapy on biochemical and histopathological changes, oxidative stress, and bacterial translocation (BT) in the experimental rat acute pancreatitis (AP). METHODS:Eighty-five Sprague-Dawley rats were included in the study. Fifteen of the eighty-five rats were used as controls (sham, GroupⅠ). AP was induced via intraductal taurocholate infusion in the remaining seventy rats. Rats that survived to induction of acute necrotizing pancreatitis were randomized into four groups. Group Ⅱ received saline, Group Ⅲ allopurinol, Group Ⅳ allopurinol plus HBO and Group Ⅴ HBO alone. Serum amylase levels, oxidative stress parameters, BT and histopathologic scores were determined. RESULTS:Serum amylase levels were lower in Groups Ⅲ, Ⅳ and Ⅴ compared to Group Ⅱ (974 ± 110, 384 ± 40, 851 ± 56, and 1664 ± 234 U/L, respectively, P < 0.05, for all). Combining the two treatment options revealed significantly lower median [25-75 percentiles] histopathological scores when compared to individual administrations (13 [12.5-15] in allopurinol group, 9.5 [7-11.75] in HBO group,[6][7].5] in combined group, P < 0.01). Oxidative stress markers were significantly better in all treatment groups compared to the controls. Bacterial translocation into the pancreas and mesenteric lymph nodes was lower in Groups Ⅲ, Ⅳ and Ⅴ compared to Group Ⅱ (54%, 23%, 50% vs 100% for translocation to pancreas, and 62%, 46%, 58% vs 100% for translocation to mesenteric lymph nodes, respectively, P < 0.05 for all). CONCLUSION:The present study confirms the benefit of HBO and allopurinol treatment when administered separately in experimental rat AP. Combination of these treatment options appears to prevent progression of pancreatic injury parameters more effectively.

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Reduction of Postischemic Edema with Hyperbaric Oxygen

Cited by 177 publications

References 0 publications

Effects of different exposures of hyperbaric oxygen on ligament healing in rats

Effects of different exposures of hyperbaric oxygen on ligament healing in rats

Effect of hyperbaric oxygen on the regeneration of experimental crush injuries of nerves

Combination of allopurinol and hyperbaric oxygen therapy: A new treatment in experimental acute necrotizing pancreatitis?

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