Reduction of oedema formation after preconditioning with dopamine in an isolated rat lung model is mediated by adrenergic receptors

Hanusch, C; Hauser, Charlotte; Geisler, Antje; Nowak, Kai; Dacho, Andreas; Ackern, K. van; Beck, Grietje

doi:10.12659/aot.882001

Cited by 5 publications

(3 citation statements)

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“…In addition, dopamine increased the tolerance of lungs to withstand tissue damage from hypothermic preservation in an isolated ventilation/perfusion model of the rat. Dopamine pretreatment stabilized endothelial barrier function of lungs subjected to prolonged cold ischemia and resulted in significant less edema formation upon re‐warming . These findings underscore that the concept of dopamine donor pretreatment may serve for a trans‐organ, systemic approach in transplantation and is not limited to the kidney graft.…”

Section: Effect On the Performance Of Non‐renal Graftsmentioning

confidence: 68%

“…Dopamine pretreatment stabilized endothelial barrier function of lungs subjected to prolonged cold ischemia and resulted in significant less edema formation upon re-warming. 49,50 These findings underscore that the concept of dopamine donor pretreatment may serve for a transorgan, systemic approach in transplantation and is not limited to the kidney graft.…”

Section: Effec T On the Performan Ce Of Non -Renal G R Af Tsmentioning

confidence: 84%

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Dopamine in transplantation: Written off or comeback with novel indication?

Schnuelle¹,

Benck

Yard

2018

Clinical Transplantation

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Renal-dose dopamine has fallen out of favor in the intensive care unit (ICU) during past years due to its ineffectiveness to prevent impending or to ameliorate overt renal failure in the critically ill. By contrast, growing evidence indicates that low-dose dopamine administered to the stable organ donor after brain death confirmation improves the clinical course of transplanted organs after kidney and heart transplantation. Ensuring a thorough monitoring for potential circulatory side effects, employment of dopamine at a dose of 4 μg/kg/min is safe in the deceased donor. Among recipients, the advantageous effect is easy to achieve, inexpensive, and devoid of adverse side effects. The mode of action relies on dopamine's propensity to mitigate injury in various cell systems from isolated transplantable organs under cold storage conditions. The present review article summarizes the clinical evidence of dopamine donor pretreatment in solid organ transplantation and focuses on the underlying molecular mechanisms of cellular protection. Introducing the routine use of low-dose dopamine for the management of the brain-dead donor in the ICU before procurement provides an evidence-based strategy to improve graft outcome after kidney transplantation without conferring harm to non-renal grafts, namely to livers and hearts, in cases of multi-organ donation.

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Section: Effect On the Performance Of Non‐renal Graftsmentioning

confidence: 68%

Section: Effec T On the Performan Ce Of Non -Renal G R Af Tsmentioning

confidence: 84%

Dopamine in transplantation: Written off or comeback with novel indication?

Schnuelle¹,

Benck

Yard

2018

Clinical Transplantation

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“…It is unknown by which mechanism DA reduces edema formation and inflammation. Hanusch et al studied the effect of dopamine on edema formation and inflammation of the lung in a rat model, and indicated that dopamine-mediated protective effects on I/R damage and inflammation in donor lungs most likely occur via adrenergic receptors [6]. …”

Section: Organ Donation and Kidney Transplantationmentioning

confidence: 99%

Progress in abdominal organ transplantation

et al. 2011

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SummaryThe excellent results of vascularized organ transplantation have resulted in an increasing number of end-stage organ failure patients seeking such treatment. The results of organ transplantation depend on a number of factors – the quality of the donor (and an organ), living vs. deceased donation, magnitude of ischemic injury (and its prevention), and recipient-dependent factors. Ischemia/reperfusion injury in organ transplantation is a multifactorial process, which may lead to delayed graft function. In addition, surgical and preservation techniques, type of immunosuppressive regimens, complications after transplantation and post-transplant management may also have a significant impact on short- and long-term results of transplantation. In this paper we describe advances in transplantation in recent years, with particular emphasis on kidney, liver, intestines, whole pancreas and pancreatic islets.

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