Reduction of Na/K-ATPase Potentiates Marinobufagenin-induced Cardiac Dysfunction and Myocyte Apoptosis

Liu, Changxuan; Bai, Yan; Chen, Yiliang; Wang, Yu; Sottejeau, Yoann; Liu, Lijun; Li, Xiaomei; Lingrel, Jerry B.; Malhotra, Deepak; Cooper, Christopher J.; Shapiro, Joseph I.; Xie, Zijian; Tian, Jiang

doi:10.1074/jbc.m111.304451

Cited by 40 publications

(60 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the hallmarks of HF. Recently, it has been found that a reduction in Na C /K C -ATPase levels in cardiac tissue induces myocyte death and cardiac dysfunction (Liu et al 2012), thus possibly leading to the development of myocardial dilation and HF. Norgaard et al (1988) also reported that decreased Na C /K C -ATPase concentration may be of importance for myocardial dysfunction and dilated cardiomyopathy.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

“…Ca 2C oscillations generated by the Na C /K C -ATPase-IP3R complex have a low frequency and activate the pleiotropic transcriptional factor nuclear factor kappa B (NFkB), which protects from apoptosis , Khodus et al 2011. During several pathological situations (cardiac insufficiency and HF) and in obesity experimental models, the heart becomes more sensitive to the effect of CGs due to a decrease in the number of Na C /K C -ATPase molecules (Shamraj et al 1993, Koksoy 2002, Liu et al 2012. Therefore, the regulation of Na C /K C -ATPase activity and expression may be important for the treatment and possible prevention of these diseases ( Fig.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

“…1; Iannello et al 2007a,b). A decrease in cardiac Na C /K C -ATPase activity or protein concentration contributes to the deficiencies in cardiac contractility in animal models and has been documented in patients with heart failure (HF; Schwinger et al 2003, Liu et al 2012. The majority of hormones (e.g.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases

Obradović¹,

Bjelogrlić²,

Rizzo³

et al. 2013

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Journal Of Endocrinologymentioning

confidence: 99%

Section: Journal Of Endocrinologymentioning

confidence: 99%

See 1 more Smart Citation

Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases

Obradović¹,

Bjelogrlić²,

Rizzo³

et al. 2013

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Studies have found that MBG activated pre-fibrotic signal, which could activate various signaling pathways and EGFR signals by inhibiting NKA, leaded to degeneration of the left ventricular muscle fli-1 and inducing collagen -1 synthesis (Elkareh et al, 2009;Liu et al, 2012;Xie et al, 2013). Study found myocardial fibrosis and siginificant elevation of MBG level in rats with a minipump for infusing MBG and rats had uremia myocarditis (Elkareh et al, 2007).…”

Section: Marinobufagenin and Fibrosismentioning

confidence: 99%

“…Although in the short term, the effect of MBG might balance the high salt load and slow the elevation of blood pressure (Mou et al, 2014), the vasoconstrictive effected by inhibiting NKA may be the long-term response of MBG. In addition, Dietary sodium restriction did not reduce level of plasma MBG (Jablonski et al, 2013).Studies have found that MBG activated pre-fibrotic signal, which could activate various signaling pathways and EGFR signals by inhibiting NKA, leaded to degeneration of the left ventricular muscle fli-1 and inducing collagen -1 synthesis (Elkareh et al, 2009;Liu et al, 2012;Xie et al, 2013). Study found myocardial fibrosis and siginificant elevation of MBG level in rats with a minipump for infusing MBG and rats had uremia myocarditis (Elkareh et al, 2007).…”

mentioning

confidence: 98%

Research Progress of Marinobufagenin and Salt-Sensitive Hypertension

Yuan¹,

Xiaoxiao²,

Xinghui³

et al. 2018

gab

View full text Add to dashboard Cite

Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the unitary ligand of Na + /K + ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention, increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na + /K + ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.Keywords Marinobufagenin; Salt-sensitive hypertension; Na + /K + -ATPase; Endogenous digitals-like substance Salt-Sensitive HypertensionSalt is one of the crucial risk factors of essential hypertension. A mass of clinical observations, animal experiments and ecological studies have documented the intimate association between salt and blood pressure.The different blood pressure response of individuals to salt load showed a discrete distribution, which confirmed the presence of salt sensitivity. Salt sensitivity is the genetic basis of salt connects hypertension, is an intermediate genetic phenotype of essential hypertension. The salt sensitivity of blood pressure, defined as an exaggerated pressor response to dietary salt intake, jointly determined by genetic factors, age, body mass index (BMI), concomitant diseases, ethnic factor, increases the risk of hypertension (Carey et al., 2012; Kotchen et al., 2013;Felder et al., 2013;Frame et al., 2017), and the associated hypertension defined as salt sensitivity hypertension (salt-sensitive hypertension, SSH). Some people have significant blood pressure increase after high salt intake is called salt-sensitive subjects, while the other group have no obvious increase in blood pressure is called non-salt-sensitive subjects. SSH is an important characteristic of hypertension in China, affects approximately 50% of hypertensive patients, 25% of normotensive adults (Kotchen et al., 2013;Felder et al., 2013 ) and about 40% of the teenages have salt sensitivity in positive family history of hypertension (Mou et al, 2012). It is a complex disease related to regional, ethnic, demographic and social factors, as well as an independent risk factor for cardiovascular disease. Endogenous Digitals-like Substance and MarinobufageninEndogenous digitals-like substance (ELDS)， which has similar characters with exogenous digitalis in structure, physico and chemical properties and biological functionis, is classified into two groups. Endogenous cardenolids have similar structure with digitalatis from plant, including endogenous ouabain (EO) and endogenous digoxin. Another group is endogenous bufadienolides, including endogenous marinobufagenin (MBG), telocinobufagin and bufalin， which have similar structure with bufotoxin that originally disc...

show abstract

Differences in morphology and in composition and release of parotoid gland secretion in introduced cane toads (Rhinella marina) from established populations in Florida, USA

Gardner

Kepas

Simons

et al. 2020

Ecology and Evolution

View full text Add to dashboard Cite

show abstract

Reduction of Na/K-ATPase Potentiates Marinobufagenin-induced Cardiac Dysfunction and Myocyte Apoptosis

Cited by 40 publications

References 37 publications

Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases

Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular diseases

Research Progress of Marinobufagenin and Salt-Sensitive Hypertension

Differences in morphology and in composition and release of parotoid gland secretion in introduced cane toads (Rhinella marina) from established populations in Florida, USA

Contact Info

Product

Resources

About