Carbon monoxide (CO) is a gasotransmitter produced in humans. An
essential unanswered question in the design of carbon monoxide releasing
molecules (CORMs) is whether the delivery molecule should be localized
extra- or intracellularly to produce desired biological effects. Herein
we show that extracellular CO release is less toxic and is sufficient
to produce an anti-inflammatory effect similar to that of intracellular
CO release at nanomolar concentrations. This information is valuable
for the design of CORMs.
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This report describes the utilization of the redox-active nature of a BODIPY dye to generate a Rh-based catalyst that is capable of exhibiting redox switchable catalytic behavior for the hydroboration of alkenes through a BODIPY-based redox event.
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