Reduction of Left Ventricular Hypertrophy After Exercise and Weight Loss in Overweight Patients With Mild Hypertension

Hinderliter, Alan L.; Sherwood, Andrew; Gullette, Elizabeth C. D.; Babyak, Michael A.; Waugh, Robert; Georgiades, Anastasia; Blumenthal, James A.

doi:10.1001/archinte.162.12.1333

Cited by 92 publications

(41 citation statements)

References 37 publications

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“…The effect of weight reduction on LV geometry and mass through diet control and exercise programs was reported to be minor and even variable (7,31). The relatively small magnitude of weight loss in these programs may explain this result.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity

Hsuan

Huang

Lin

et al. 2010

Obesity

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The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty‐six severely obese adults (BMI ≥35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction.

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Section: Discussionmentioning

confidence: 99%

The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity

Hsuan

Huang

Lin

et al. 2010

Obesity

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“…e effects of exercise training on cardiac remodeling in hypertensive human subjects have been reviewed elsewhere [63] and have shown equivocal results with some studies showing no change in le ventricular mass [64][65][66][67][68][69], a decrease in le ventricular mass/le ventricular mass index [64,[70][71][72][73][74], and an increase in le ventricular mass/le ventricular mass index [5,66]. e majority of these studies showed that systolic and diastolic blood pressure was reduced following exercise, and imaging was most oen measured with M-mode and 2D guided echocardiography.…”

Section: Cardiac Remodelingmentioning

confidence: 99%

Cardiac Effects of Exercise Training in Hypertension

Libonati

2013

ISRN Hypertension

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Hypertension is a signi�cant health concern. Hypertension leads to compensatory pathologic hypertrophy and impaired cardiac function. Lifestyle modi�cations such as exercise are encouraged for hypertensive patients. Some studies have shown that exercise training can reverse pathological hypertrophy. Conversely, studies on animal models of hypertension have shown increased cardiac growth with exercise training. Despite the further induction of hypertrophy, exercise training seems protective against cell death and may increase cardiomyocyte proliferation, leading to a putative phenotype. �ne of the hallmark bene�cial effects of exercise in hypertension is an improvement in myocardial adrenergic responsiveness. e focus of this paper is to discuss how exercise training impacts cardiac remodeling and function in the hypertensive heart with speci�c reference to adrenergic signaling.

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“…The mechanism of reduction in muscle mass in myocardium by ACE inhibitor treatment is thought to be due to inhibition of myocardial fibrosis thereby reversing hypertrophy (Crisman et al 1985) . The effect of exercise on muscle mass in hypertension is controversial with various studies indicating both hypertrophy as a result of exercise (Barnard, et al 1980) and a reduction in hypertrophy (Hinderliter, et al 2002). There were others however, indicating no significant change in muscle mass due to exercise (Bersohn and Scheuer 1977).…”

Section: Discussionmentioning

confidence: 99%

“…Others have suggested that moderate exercise in humans reduces left ventricular hypertrophy (Himeno, et al 1996;Hinderliter, et al 2002) . Moderate exercise has been shown to also induced myocardial capillary growth in the spontaneously hypertensive rat (Crisman et al 1985).…”

Section: Introductionmentioning

confidence: 99%

Volumetric changes in the components of left ventricle myocardium of spontaneously hypertensive rats following exercise and ACE inhibitor treatment

Inuwa¹,

Hassan²,

Ziada³

2006

African Journal of Biomedical Research

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This study was designed to test the possible effects of a combination of physical and pharmacological therapy intervention on myocardial structure of the left ventricle in spontaneously hypertensive rats (SHR). Forty 12 weeks old spontaneously hypertensive rats were divided into four groups of sedentary, Sed as controls, exercise only , (Exer), lisinopril only 20mg/kg/day, ( Lis) , and exercise + lisinopril, (LisExer). Exercise training was performed on a treadmill (5m/min.) for 60 minutes/day, 5 days/week for 10 weeks. At the end of 10 weeks, all the rats were terminally anaesthetised, the heart was arrested in diastole by intravenous procaine and whole animal perfusion fixation through the abdominal aorta was carried out using Karnovsky's fixative (Ph 7.24). The heart was removed and left ventricle plus the interventricular septum was serially sectioned at a thickness of three millimetres. One piece was randomly chosen, and embedded in JB4 resin. Six sections were obtained from each block, stained with toluidine blue:acid fucin. Measurement of volume fraction V f , of myocardial components was carried out using Histometrix MIL6 Ver 1.0 stereology software ( Kinetic imaging Ltd.). Mean volume fraction, V f of capillaries in Sed. group was 0.114 ± 0.01 (SEM). This was significantly increased in LisExer group. The volume fraction of muscle in Sed group was 0.795 ± 0.02 (SEM). This was significantly decreased in Lis but unchanged in Exer group. Capillaries V f was significantly higher in LisExer as compared to Lis or Exer groups (p<0.05). Muscle V f was not different between LisExer and Lis groups. The outcome of these changes could well be a better enhancement of cardiac performance in hypertension by combined exercise and ACE inhibitor treatment than either of the interventions alone.

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Reduction of Left Ventricular Hypertrophy After Exercise and Weight Loss in Overweight Patients With Mild Hypertension

Abstract: In a cohort of overweight, sedentary men and women, exercise and weight loss reduced blood pressure and induced favorable changes in left ventricular structure.

Cited by 92 publications

References 37 publications

The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity

The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity

Cardiac Effects of Exercise Training in Hypertension

Volumetric changes in the components of left ventricle myocardium of spontaneously hypertensive rats following exercise and ACE inhibitor treatment

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