Reduction of heparin binding to and inhibition of platelets by aprotinin

RETRACTED ARTICLE: Does continuous heparinization influence platelet function in the intensive care patient?

“…John et al [23] have shown severe inhibition of platelet function with heparin in patients undergoing cardiac surgery. It has recently been demonstrated with hemostatometry that bleeding after cardiopulmonary bypass may be due to inhibition of platelet function by heparin [24].…”

"Phlebomania Hancocksia": prevalence of a previously undescribed psychomotor disturbance

“…I prospectively diagnosed and recorded the presence of phlebomania Hancocksia in 290 cardiac surgical patients involved in the study 1 2 3. Fifty two patients (18%) showed the disturbance.…”

“…While we were taking blood samples from cardiac surgical patients to study platelet function and blood loss1 2 3 we observed a common phenomenon. Several patients asked how much blood was going to be taken, and a proportion of them responded uniformly to the reply that it was to be only enough for one large syringe.…”

Effects of Aprotinin During Cardiopulmonary Bypass in Patients Treated with Acetylsalicylic Acid

“…Aprotinin, moreover, was found to influence thromboxane B 2 in endothelial cells, leading to enhanced platelet aggregation and improved vascular sealing (12). There is also evidence that aprotinin reduces heparin binding to platelets and thereby mitigates heparin-induced platelet dysfunction (13).…”

“…It is a relatively nonspecific serine protease inhibitor of 58 aminoacid polypeptide with a short half-life of about 2 h (10). Furthermore, several reports indicate that aprotinin protects platelet function during CPB (3,8,9,(11)(12)(13)(14).…”