Alterations of the hemostatic network were seen in all three groups of critically ill patients. Hemostasis normalized in the neurosurgery patients and posttraumatic hypercoagulability recovered within the study period. By contrast, monitoring of molecular markers of the coagulation process demonstrated abnormal hemostasis in the sepsis patients during the entire study period indicating ongoing coagulation disorders and abnormalities in fibrinolysis in these patients.
Continuous administration of heparin with an average dose of approximately 500 U/h did not negatively influence platelet function in the trauma patients. Recovery from reduced platelet function in the sepsis group was not affected by continuous heparinization. Thus, continuous heparinization with this dose appears to be safe with regard to platelet function in the intensive care patient.
The Editor-in-Chief has retracted this article. A statement by Justus Liebig University (JLU) [1] on the scientific credibility of articles by Joachim Boldt has recommended that journal editors consider retracting all articles "where Boldt is the responsible author even if there is no obvious indication of falsification". Given the concerns about the studies performed by Joachim Boldt the
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