Reduction of greenhouse gases emission through the use of tiletamine and zolazepam

Lachowska, Sonia; Antończyk, Agnieszka; Tunikowska, Joanna; Godniak, Martyna; Kiełbowicz, Zdzisław

doi:10.1038/s41598-022-13520-7

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Finally, the opportunity to use low doses of anesthetic drugs represents a challenge not only for animal health but also for the environment. The influence of anaesthetic gases on global warming is being investigated, as some authors claim that volatile anaesthetics are halogenated compounds destructive to the ozone layer, so any protocol leading to a reduction of these drugs in addition to safeguarding animal welfare may also improve environmental pollution [ 37 , 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery

Interlandi

Pietro

Costa

et al. 2022

Animals

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The purpose of the present study was to test whether the addition of cisatracurium in combination with propofol and sevoflurane would result in a change in doses of used anesthetic drugs. Ten dogs (Group A) undergoing elective unilateral mastectomy surgery were included in the study. To induce and maintain anesthesia, subjects received propofol and sevoflurane at varying doses; analgesia was performed with remifentanil. After three months, the same subjects (Group B) underwent contralateral mastectomy and received the same anesthetic protocol with the addition of cisatracurium at a dosage of 0.2 mg/kg−1. The following parameters were monitored during anesthesia: heart rate, systolic blood pressure, end-tidal CO2, oxygen saturation, halogenate requirement, and rectal temperature at baseline (T0), induction (T1), 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25), 30 (T30), and 35 (T35) time points. In Group A, halogenate requirement was reduced at all the time points other than T1 (p < 0.001); in Group B, the percentage of halogenate requirement was already reduced at T1 and remained constant during the experimental period, showing no significant intragroup differences. The dose requirements of sevoflurane and propofol varied significantly between the two groups, with significantly lower dosages in the Group B (the cisatracurium-treated group). Moreover, patients treated with cisatracurium showed a stable anesthetic plan. The nondepolarizing-muscle-relaxant cisatracurium besylate could be considered a useful adjunct to anesthetic protocols.

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Section: Discussionmentioning

confidence: 99%

Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery

Interlandi

Pietro

Costa

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…Many of these emissions have zero-emission options available, often with cost efficiency gains. One significant industry specific challenge for Scope 1 reduction in the veterinary sector is to achieve a zero-emission alternative to current anesthetic gas use (16,(28)(29)(30)52).…”

Section: Reducing Emissionsmentioning

confidence: 99%

The path to Net Zero carbon emissions for veterinary practice

Watson,

Klupiec,

Bindloss

et al. 2023

Front. Vet. Sci.

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The urgent need to reduce greenhouse gas emissions in line with the Paris Agreement is a compelling reason for the entire veterinary profession to act on climate change because of its impact on animal health. The aim of this perspective is to provide a business framework that veterinary practices can use to implement the path to Net Zero carbon emissions. Practice management is identified as a key stakeholder capable of implementing significant change within the sector. Climate related business opportunities and challenges are identified and integrated into a stepwise process for practices to follow. The pathway requires establishing a culture of sustainability within the veterinary team, measuring and reporting emissions, setting targets and systematically prioritizing reductions. Practices can begin this process immediately by reducing emissions under direct control of the business (Scope 1) and emissions from electricity purchases (Scope 2). To complete the pathway, emissions from all other activities (Scope 3) will need to be reduced and offset. Reduction of Scope 3 emissions is more challenging and will require collaboration between all supply chain stakeholders. The progression of climate change is now inevitable and a proactive approach from veterinary leaders, in particular practice management, will provide new opportunities, manage risks and inspire the broader veterinary sector to join their efforts to achieve a better future for animal health.

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Antimicrobial Activity against Antibiotic-resistant Pathogens and Antioxidant Activity and LCMS/MS Phytochemical Content Analysis of Selected Medicinal Plants

Thakur,

Khushboo,

Yadav

et al. 2024

J. Pure Appl. Microbiol.

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Medicinal plants are a major source of numerous therapeutic agents, and the emergence of pathogenic bacteria has rekindled interest in traditional medicine systems as an alternative approach to overcoming resistance. The dried plant material of four medicinal plants, namely Terminalia arjuna (bark), Terminalia bellirica (fruit), Aegle marmelos (leaves), and Bacopa monnieri (leaves), was powdered, and aqueous extracts were prepared. The antimicrobial activity of the extracts was evaluated against three clinically important strains: Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli 385. As E. coli 385 was resistant to the broadest spectrum of antibiotics tested, it was classified as (MDR multi-drug resistant). E. coli, Bacillus subtilis, Mycobacterium smegmatis (MTTC), and Vibrio alginolyticus (ATCC) were also assessed using the agar well diffusion method for zones of inhibition and minimum inhibitory/bactericidal concentration (MIC/MBC). Clinically important strains were found to be sensitive to the aqueous extract of T. bellerica (19.51 ± 0.61 mm) with MICs ranging from 0.31 to 0.62 mg/ml. The MDR strain was also sensitive to Bellirica monnieri (16.10 ± 0.31 mm) aqueous extract. To determine the potential for a wide range of applications, the antioxidant activities of the extracts were evaluated using DPPH, ABTS, and FRAP assays. The T. arjuna plant extract exhibited the highest radical scavenging activity with the lowest EC50 values for DPPH (1.15 ± 0.061 mg/ml) and ABTS (1.02 ± 0.07 mg/ml). The plant extracts were characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy, and LC-MS/MS.

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Reduction of greenhouse gases emission through the use of tiletamine and zolazepam

Cited by 3 publications

References 56 publications

Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery

Effects of Cisatracurium in Sevoflurane and Propofol Requirements in Dog-Undergoing-Mastectomy Surgery

The path to Net Zero carbon emissions for veterinary practice

Antimicrobial Activity against Antibiotic-resistant Pathogens and Antioxidant Activity and LCMS/MS Phytochemical Content Analysis of Selected Medicinal Plants

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