Reduction of Cu(II) and Riboflavin in DIOS Mass Spectrometry

Okuno, S.; Arakawa, Ryuichi; Wada, Yoshinao

doi:10.5702/massspec.52.13

Cited by 16 publications

(25 citation statements)

References 29 publications

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“…Observation of a similar copper reduction in the DIOS experiments that were performed suggests that the silicon surface acts as a reducing agent. It should be noted that this copper reduction in DIOS has been observed in the case of the riboflavin compounds 26. The absence of stable Cu II trimeric anions suggests that Cu II is likely to have been completely reduced to Cu I .…”

Section: Resultsmentioning

confidence: 59%

Desorption/ionization on porous silicon mass spectrometry (DIOS) of model cationized fatty acids

et al. 2006

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Desorption/ionization on porous silicon (DIOS) is a very useful technique in the case of small molecular weight compounds, compared to the matrix-assisted laser desorption ionization (MALDI). This is because MALDI generates matrix-related ions that overlap with the mass range of interest. The aim of our work was to investigate the suitability of the DIOS technique in the case of fatty acids in negative ion mode. The analysis of the chosen fatty acid models, nonadecanoic acid (C(19)H(38)O(2)) and heneicosanoic acid (C(21)H(42)O(2)), gave rise to the observation of the deprotonated monomeric species and selective cationized multimeric species. This cation selectivity was further elucidated by complementary studies based on the addition of various metals such as Ag(I), Zn(II), Fe(II), and also Cu(II). Specific behavior, depending upon the introduced metal, was highlighted by different redox reaction processes and also metastable decompositions (in PSD mode).

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Section: Resultsmentioning

confidence: 59%

Desorption/ionization on porous silicon mass spectrometry (DIOS) of model cationized fatty acids

et al. 2006

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“…The organic dyes are often reduced in the various desorption/ionization methods including MALDI,8 desorption ionization on porous silicon (DIOS),8 fast atom bombardment (FAB),9 secondary ion mass spectrometry (SIMS)10, 11 and plasma desorption (PD) ionization 11. Riboflavin was also found to be reduced in FAB,12 MALDI,12 and DIOS 13. The extent of reduction reactions for organic dye and riboflavin depends on the reduction potential of analyte molecules11 and on the types of matrixes used 8, 9, 11…”

Section: Introductionmentioning

confidence: 99%

Study on the redox reactions for organic dyes and S‐nitrosylated peptide in electrospray droplet impact

Asakawa

Hiraoka

2008

J. Mass Spectrom.

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Reduction of analytes in ionization processes often obscures the determination of molecular structure. The reduction of analytes is found to take place in various desorption/ionization methods such as fast atom bombardment (FAB), secondary ion mass spectrometry (SIMS), matrix-assisted laser desorption/ionization (MALDI) and desorption ionization on porous silicon (DIOS). To examine the extent of the reduction reactions taking place in electrospray droplet impact (EDI) processes, reduction-sensitive dyes and S-nitrosylated peptide were analyzed by EDI. No reduction was observed for methylene blue. While methyl red has a lower reduction potential than methylene blue, the reduction product ions were detected. For S-nitrosylated peptide, protonated molecule ion [M + H](+) and NO-eliminated molecular ion [M - NO + H](+*) were observed but reduction reactions are largely suppressed in EDI compared with that in MALDI. As such, the analytes examined suffer from little reduction reactions in EDI.

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“…Afterwards, the reactants as well as the products could be extracted by the electric field and analyzed in the mass spectrometer. �rimary studies on in-source redox reactions during NALDI include oxidation of ferrocene derivatives and reduction of organic dyes during DIOS [91][92][93]. Recently, we employed TiO 2 nanoparticle modinanoparticle modiparticle modified substrates to perform on-line redox reactions on biomolecules coupled with MS analysis [30][31][32].…”

Section: Nanomaterials To Induce In-source Reaction During the Maldi mentioning

confidence: 99%

Nanomaterial-Assisted Laser Desorption Ionization for Mass Spectrometry-Based Biomedical Analysis

Qiao

Liu

2010

Nanomedicine

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Nanomaterials have been widely used to assist laser desorption ionization of biomolecules for mass spectrometry analysis. Compared with classical matrix-assisted laser desorption ionization, strategies based on nanomaterial-assisted ionization generate a clean background, which is of great benefit for the qualitative and quantitative analysis of small biomolecules, such as therapeutic and diagnostic molecules. As label-free platforms, they have successfully been used for high-throughput enzyme activity/inhibition monitoring and also for tissue imaging to map in situ the distribution of peptides, metabolites and drugs. In addition to widely used porous silicon nanomaterials, gold nanoparticles can be easily chemically modified by thiol-containing compounds, opening novel interesting perspectives. Such functionalized nanoparticles have been used both as probes to extract target molecules and as matrices to assist laser desorption ionization for developing new enzyme immunoassays or for studying DNA hybridization. More recently, semiconductor nanomaterials or quantum dots acting as photosensitive centers to induce in-source redox reactions for proteomics and to investigate biomolecule oxidation for metabolomics have been shown to offer new analytical strategies.

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Reduction of Cu(II) and Riboflavin in DIOS Mass Spectrometry

Cited by 16 publications

References 29 publications

Desorption/ionization on porous silicon mass spectrometry (DIOS) of model cationized fatty acids

Desorption/ionization on porous silicon mass spectrometry (DIOS) of model cationized fatty acids

Study on the redox reactions for organic dyes and S‐nitrosylated peptide in electrospray droplet impact

Nanomaterial-Assisted Laser Desorption Ionization for Mass Spectrometry-Based Biomedical Analysis

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