Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany

Horn, Johannes; Denecke, Agnieszka; Luyten, Alexander; Rothe, Beate; Reinecke-Lüthge, Axel; Mikolajczyk, Rafael; Petry, Karl Ulrich

doi:10.1038/s41416-019-0453-2

Cited by 28 publications

(18 citation statements)

References 24 publications

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“…We found also one observational study from Germany, which was conducted in the framework of a routine local cervical cancer screening program using Papanicolaou smear and Hybrid Capture 2 (HC2) HPV co‐testing, and which extended over more than one screening round (Table 5). 27 Unfortunately, no data on colposcopy referrals were given, but both the histological HSIL+ and invasive cervical cancer rates declined significantly in the later screening rounds compared with the first round.…”

Section: Discussionmentioning

confidence: 99%

Primary HPV screening for cervical cancer: Results after two screening rounds in a regional screening program in Finland

Veijalainen

Kares

Kotaniemi-Talonen

et al. 2020

Acta Obstet Gynecol Scand

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Introduction Since 2012, cervical cancer screening has been conducted with a primary high‐risk human papillomavirus (hrHPV) test and conventional cytology triage in the city of Tampere, Finland. The women who were screened with the hrHPV test in 2012 were invited to participate in the second screening round in 2017. The aim of the present report was to compare the number of colposcopy referrals and the number of histological high‐grade squamous intraepithelial lesion (HSIL)+ (cervical intraepithelial neoplasia [CIN2+]) lesions between the first and second screening rounds of women of a specific age group who were screened twice with the hrHPV test. Material and methods The primary hrHPV test used was the RealTime hrHPV PCR assay by Abbott. Women with a positive hrHPV test and cytology triage equal to or worse than low‐grade squamous intraepithelial lesion or atypical glandular cells, favor neoplasia, were directly referred to colposcopy, whereas hrHPV‐positive women with a negative or equivocal cytology triage were re‐screened after approximately 12‐16 months. hrHPV‐negative women were scheduled for re‐screening after 5 years. The present report focuses on the cohort of women who were screened twice with the hrHPV test, who were 35‐55 years old in 2012, and 40‐60 years old in 2017. Results In all, 8076 women were invited for HPV screening in 2012 and 8331 women were invited for the second round 5 years later, with attendance rates of 70% and 71%, respectively. Of the women who were screened in 2012, 4571 (69%) belonged to the 35‐ to 55‐year age cohort. In 2017, 4807 (73%) of the women aged 40‐60 years participated in the screening. In this cohort, 185 (4.0%) colposcopies were performed in the first screening round, compared with 139 (2.9%) in the second round, and the colposcopy rate was 29% smaller in the second round (P = .002). The number of histological HSIL+ cases was 38 (0.8%) during the first screening round and 29 (0.6%) during the second round (P = .220). Conclusions In the setting of routine organized cervical cancer screening, the initially high colposcopy rate associated with primary HPV screening seems to level off at the second screening round in women who were screened twice with an hrHPV test.

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Section: Discussionmentioning

confidence: 99%

Primary HPV screening for cervical cancer: Results after two screening rounds in a regional screening program in Finland

Veijalainen

Kares

Kotaniemi-Talonen

et al. 2020

Acta Obstet Gynecol Scand

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“…The failure rate for colposcopy to detect CIN 3 is higher in cases of QPHP with NILM cytology compared with QPHP and abnormal cytology. 57 These findings require further research before guideline panels could consider an alternative to colposcopy for women with SGTP and NILM cytology and genotypes of lowest risk.…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review

Bonde

Bottari

Iacobone

et al. 2020

J Low Genit Tract Dis

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“…Its sensitivity seems to be significantly higher than that of cytology [5]. Pap smear screening programs continue to be practiced and significantly reduce the incidence of cervical cancer and its mortality, especially in countries with high population coverage [6].…”

Section: Introductionmentioning

confidence: 99%

“…However, one of the limitations of cytology-based screening is its low sensitivity detecting of dysplastic lesions in cervical cancer (intraepithelial neoplasia CIN ≥ 2). In addition to the need for repeated screening at short intervals, there is a high probability that false negative results will be repeated [6].…”

Section: Introductionmentioning

confidence: 99%

The Place of Human Papillomavirus Test in the Screening of Intraepithelial Lesions of Cervix in South-Kivu Province, DR Congo

Nyakio¹,

Fabrice²,

Bertin³

et al. 2021

OJOG

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Introduction: Human papillomavirus (HPV) infection remains the most common cause of cervical intraepithelial neoplasia. The objective of this study is to evaluate the sensitivity and predictive value of the HPV test associated with the cervico-uterine smear in the screening of cervical intraepithelial neoplasia in our environment. Methodology: This is a descriptive cross-sectional study of 625 women who consulted in the department of gynecology for cervical cancer screening, of whom 300 received an HPV test; during the period from January the 1st to December 31st, 2018 at Panzi general reference hospital (South-Kivu, DRC). Data analysis was done using Epi Info version 7 software. Results: For all respondents (n = 625), the cervico-uterine smear was normal in 82.88%, inflammatory in 2.4% of cases and with cellular atypia in 14.72%. The HPV test was positive in 87 respondents against 213 negatives cases, i.e. a prevalence of HPV of 29% [95% CI: 23.9% -34.5%]. Among women with precancerous lesions, 27.6% had HPV infection; among those with normal smears, 29.3% of them had HPV infection; however, this difference was not statistically significant. Patients with dysplastic lesions, 31.3% had genotypes with very high carcinogenic potential; and for those with a normal Pap smear, 45.1% had genotypes with very high carcinogenic potential; however, this difference was also not statistically significant. Conclusion: The human papillomavirus test remains a very important indication

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Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany

Cited by 28 publications

References 24 publications

Primary HPV screening for cervical cancer: Results after two screening rounds in a regional screening program in Finland

Primary HPV screening for cervical cancer: Results after two screening rounds in a regional screening program in Finland

Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review

The Place of Human Papillomavirus Test in the Screening of Intraepithelial Lesions of Cervix in South-Kivu Province, DR Congo

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