Reduction of cardiac and pulmonary complication probabilities after breathing adapted radiotherapy for breast cancer

Translucent poly(vinyl alcohol) cryogel dosimeters for simultaneous dose buildup and monitoring during chest wall radiation therapy

“…In this context, a gamma pass rate less than a prescribed amount would indicate an unacceptable variation in patient position. Existing studies suggest that setup errors in the A/P direction can range from approximately 2 to 5 mm 14 , 15 . Additional studies have shown that patients may shift their chest wall position during free breathing (FB), BH, and DIBH by 2.5 2.7 and 4.6 mm, respectively 7 , 8 , 14 , 15 .…”

“…Existing studies suggest that setup errors in the A/P direction can range from approximately 2 to 5 mm 14 , 15 . Additional studies have shown that patients may shift their chest wall position during free breathing (FB), BH, and DIBH by 2.5 2.7 and 4.6 mm, respectively 7 , 8 , 14 , 15 . Similarly, uncertainty in the superior/inferior (S/I) direction may also be significant during DIBH delivery, where patient‐induced shifts may be as large as 6.6 mm (7) .…”

“…Positioning uncertainties and breathing motions can introduce a significant deviation between planned and delivered dose distribution (13) . The typical maximum uncertainties/setup errors involved in left breast and chest wall treatment in the A/P direction (vertical chest wall excursion over the treatment duration) have been reported to be as large as 5 mm 13 , 14 , 15 . Patient‐induced chest wall shifts of a similar magnitude during DIBH have also been reported 7 , 8 …”

The comparison of the radiation load to the heart and the left anterior descending coronary artery for various modes of radiation treatment of the breast cancer patients

“…Изучение разных вариантов облучения и позицио-нирования пациентов в целях снижения дозы на ор-ганы риска и сравнения покрытия мишени показало, что проведение ЛТ с управляемой задержкой дыха-ния приводит к снижению лучевой нагрузки на сердце и легкие, так как на вдохе происходит пространствен-ное разобщение сердца и облучаемого объема мишени и снижение плотности легочной ткани [10].…”

The role of image guidance in respiratory gated radiotherapy

“…It has been shown that by treating only in the inspiration phase of free breathing or breathing with enhanced inspiration, the doses to both heart and lungs can be reduced significantly [20,18,28]. Administering radiation only during deep inspiration has shown reductions of heart doses up to 80Á90% (of volume receiving more than 50% of prescription dose), corresponding to a decrease in cardiac mortality risk down to 1 (calculated by a normal tissue complication probability model [19]).…”