Reduction in pulse wave velocity and improvement of aortic distensibility accompanying regression of atherosclerosis in the rhesus monkey.

Farrar, David J.; Green, H D; Bond, M. Gene

doi:10.1161/01.res.47.3.425

Cited by 104 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies 9 have shown that atherosclerosis causes reduced compliance in large elastic arteries. Farrar et al 10 also showed that producing regression of atherosclerosis in monkeys causes an increase in arterial compliance. Reduced arterial compliance in nonoccluded arteries has been demonstrated in patients with peripheral arterial disease 4 and in patients with coronary artery disease.…”

Section: Discussionmentioning

confidence: 97%

Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Relf¹,

Lo²,

Myers³

et al. 1986

Arteriosclerosis

View full text Add to dashboard Cite

Doppier ultrasound was used to measure pulse wave velocity down the aorta and iliac arteries. Arterial wall compliance was calculated from pulse wave velocity in 45 apparently healthy men. Their arterial compliance fell significantly with advancing age, raised blood pressure, increased serum cholesterol and triglyceride levels, and reduced serum high density lipoprotein cholesterol levels. The correlation between compliance and age was independent of the other risk factors, and the correlation between compliance and Iipid status was independent of age and blood pressure. There was no significant correlation between compliance and area under the glucose tolerance curve. (Arteriosclerosis 6:105-108, January/February 1986)

show abstract

Section: Discussionmentioning

confidence: 97%

Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Relf¹,

Lo²,

Myers³

et al. 1986

Arteriosclerosis

View full text Add to dashboard Cite

show abstract

“…22,23 Further studies are needed to determine whether the vascular elasticity response to NTG will change if the risk factors for atherosclerosis are controlled.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Early Stage of Carotid Atherosclerosis Using the Vascular Response to Nitroglycerin and High-Resolution Ultrasonography

et al. 1998

View full text Add to dashboard Cite

therosclerosis is a series of histopathological changes that includes intimal thickening, degenerative compositional changes of the medial layer (sclerotic change) and atheroma-formation (atherotic change). 1 The recent development of high-resolution Bmode ultrasonography has made it possible to detect and evaluate the atheromatous changes of the arteries, particulary the carotid artery. [2][3][4][5] However, despite these studies, methods that evaluate the sclerotic change of an artery, an early stage of atherosclerosis, have not been established. Vascular sclerotic changes increase vascular stiffness, and may disturb the vascular responses to a vascular relaxant. Although decreased elasticity of the arterial wall in the atherosclerotic carotid artery has been reported, 6-9 the carotid artery response to vascular relaxant has not been reported yet.Nitroglycerin (NTG), a relaxant of vascular smooth muscle, may change arterial elasticity. 10,11 If the change in elasticity of the atherosclerotic artery in response to NTG is different from that of the normal artery, evaluation of this response may be valuable in assessing atherosclerotic changes. The purpose of the present study was to determine whether the early atherosclerotic changes of the common carotid artery (CCA) could be evaluated by the response of vascular elasticity to NTG, where there was no ultrasonic atheromatous plaque. The vascular elasticity was expressed by vascular strain (VS) and pressure-strain elastic modulus (Ep). Moreover, the extent of atherosclerosis of the CCA has been shown to be strongly correlated with the extent of coronary artery disease (CAD). 12-16 Therefore, we also examined whether the decreased elasticity response of the CCA to NTG was associated with CAD. Methods Study SubjectsThe study was performed in 52 patients who were admitted for the evaluation of CAD (35 men and 17 women, aged from 45 to 74 years old ), and 9 normal male volunteers (aged from 23 to 27 years old) without risk factors for atherosclerosis such as hyperlipidemia, hypertension, glucose intolerance and smoking. Patients with frequent arrhythmias, congestive heart failure, congenital and acquired heart disease were excluded, because the hemodynamic abnormality of these diseases may affect the diameter change of the CCA. Patients with recent cerebrovascular attacks and a blood pressure difference between the bilateral brachial artery of greater than 10 mmHg were also excluded. Informed consent was obtained from every Evaluation of the Early Stage of Carotid Atherosclerosis Using the Vascular Response to Nitroglycerin and High-Resolution UltrasonographyJpn Circ J 1998; 62: 494 -498 Cha-Po Lai, MD; Samon Koyanagi, MD**; Cheng-Kuang Shaw, DDS*; Akira Takeshita, MD**The purpose of this study was to determine whether the early stages of arterial atherosclerosis could be evaluated by the vascular response to nitroglycerin (NTG). The vascular elasticity of the common carotid artery (CCA) was evaluated at sites without atheromatous plaque using high-resolution ultr...

show abstract

“…Studies in monkeys [24][25][26][27] have previously shown that a diet regimen rich in cholesterol is associated in the long term with a significant pressureindependent increase of aortic PWV, and that following a chronic hypolipidaemic diet, the regimen is associated with a further transient increase of PWV, in relation with the reduction of the lipid vascular content, a biomaterial usually considered as soft. After this early phase, the increase in PWV tends to disappear and is even reversed as a consequence of the remodelling of the vascular wall.…”

Section: Commentsmentioning

confidence: 99%

Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study

Rudnichi

2002

J Hum Hypertens

View full text Add to dashboard Cite

As statins may contribute to plaque stabilisation, it is important to evaluate whether these drugs may modify arterial stiffness. In 23 patients, aged 32-70 years, with hypertension and hypercholesterolaemia, a doubleblind randomised study vs placebo was performed to evaluate whether atorvastatin was able to modify aortic stiffness, measured from aortic pulse wave velocity (PWV), after a 12-week treatment. The results revealed that atorvastatin did not change blood pressure, significantly lowered (Po0.003; o0.002) plasma total and LDL cholesterol, and increased aortic PWV by +8% (vs À2% under placebo) (P40.05). The percentage changes in plasma total and LDL cholesterol and in PWV were significantly and negatively correlated, independent of blood pressure level. The finding of increased aortic PWV after 12-week statin treatment agrees with studies in monkeys, indicating that, at the early phase of hypolipidaemic diet but not later, aortic PWV increases transiently as a consequence of the significant reduction of lipid vascular content. In conclusion, the present results support the possibility that statins might contribute to a change in arterial stiffness independent of blood pressure level, and suggest that long-term studies in humans are needed to evaluate the contribution of arterial elasticity to statin-induced vascular remodelling.

show abstract

Reduction in pulse wave velocity and improvement of aortic distensibility accompanying regression of atherosclerosis in the rhesus monkey.

Cited by 104 publications

References 21 publications

Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Evaluation of the Early Stage of Carotid Atherosclerosis Using the Vascular Response to Nitroglycerin and High-Resolution Ultrasonography

Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study

Contact Info

Product

Resources

About