Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Relf, I R N; Lo, Che Sam; Myers, K A; Wahlqvist, Mark L.

doi:10.1161/01.atv.6.1.105

Cited by 43 publications

(27 citation statements)

References 10 publications

(7 reference statements)

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“…Serum glucose or insulin or both have been found to be negatively associated with arterial distensibility in several studies [9, 29±31, 33] but some of these studies did not adequately adjust for blood pressure. One study found no correlation between area under the glucose tolerance curve and arterial distensibility after adjustment for age and blood pressure [34]. There are several possible explanations for conflicting results in these previous studies.…”

Section: Discussionmentioning

confidence: 94%

Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women

Popele¹,

Westendorp²,

Bots

et al. 2000

Diabetologia

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Clustering of risk factors for cardiovascular disease (hypertension, obesity, dyslipidaemia), resistance to insulin-stimulated glucose uptake, and cardiovascular disease is known as the insulin resistance syndrome [1]. The insulin resistance syndrome occurs in non-insulin-dependent diabetic patients but also in non-diabetic people with normal glucose tolerance. In glucose-clamp studies in non-obese subjects with normal oral glucose tolerance, resistance to insulin-stimulated glucose uptake was found in approximately 25 % of these subjects [2]. These subjects secrete high Diabetologia (2000) Abstract Aims/hypothesis. The insulin resistance syndrome is related to arterial stiffness in diabetic subjects. Whether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear. We studied the association between variables of the insulin resistance syndrome in relation to arterial distensibility in healthy middle-aged non-diabetic women. Methods. This study was done in 180 non-diabetic women, aged 43±55, selected from the general population. Arterial distensibility was assessed in the carotid artery. The associations were evaluated using linear regression analyses. Results. Strong associations were found between arterial distensibility and the variables of the insulin resistance syndrome: body mass index, waist-to-hip ratio, high-density-lipoprotein-cholesterol, triglycerides, glucose, insulin, apolipoprotein A1, plasminogen activator inhibitor-1-antigen and tissue-type plasminogen activator-antigen. After additional adjustment for mean arterial pressure, common carotid arterial distensibility remained associated with body mass index: b-coefficient (95 % confidence interval) per kg/m 2 : ±0.24 (±0.42; ±0.06); waist-to-hip ratio: ±26.62 (±40.59; ±12.65) per m/m; triglycerides: ±1.42(±2.77; ±0.08) per mmol/l; plasminogen activator inhibitor±1-antigen: ±0.01 (±0.02; ±0.00) per ng/ml and borderline significant associated with high-density-lipoprotein-cholesterol: 1.93 (±0.01; 3.87; p = 0.07) per mmol/l. Clustering of variables of the insulin resistance syndrome was strongly related to decreased arterial distensibility which remained after adjustment for mean arterial pressure. No association was found between arterial distensibility and variables that are not part of the insulin resistance syndrome: total cholesterol, LDL-cholesterol and apolipoprotein B. Conclusion/interpretation. The results of this study show that variables of the insulin resistance syndrome are associated with decreased arterial distensibility of the common carotid artery in healthy non-diabetic subjects. [Diabetologia (2000)

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Section: Discussionmentioning

confidence: 94%

Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women

Popele¹,

Westendorp²,

Bots

et al. 2000

Diabetologia

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“…Two other studies have yielded discordant results with regard to HDL cholesterol. A positive association, independent of blood pressure, between HDL cholesterol and arterial compliance has been reported in a small group of healthy men (25), whereas an inverse relationship was found in hypertensive men including both normocholesterolemic and hypercholesterolemic subjects (20). Thus, there is no clear evidence for an association between total cholesterol or lipoprotein fractions and PWV.…”

Section: Discussionmentioning

confidence: 97%

Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women

et al. 1993

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Cross-sectional associations between aortic elasticity assessed by carotid to femoral pulse wave velocity (PWV) and cardiovascular risk factors were examined in 429 apparently healthy middle-aged women. PWV was strongly and positively related to blood pressure and hypertension. Weak but significant positive associations were also found between PWV and age, heart rate, some lipids and lipoproteins, blood glucose (either as a continuous or dichotomous variable), body mass index, haematocrit, leucocyte count and family history of diabetes. No associations were observed between PWV and high density lipoprotein cholesterol, apolipoprotein A1, fibrinogen, cigarette smoking, menopausal status and a family history of hypertension or myocardial infarction. After adjustment for systolic blood pressure, PWV remained significantly related to heart rate, leucocyte count, blood glucose (as a dichotomous variable) and a family history of diabetes. Multiple regression analysis showed that systolic blood pressure and, to a lesser extent, heart rate, leucocyte count and a family history of diabetes were all independent determinants of PWV. This pattern of associations suggests that arterial stiffness measured by PWV reflects the sclerotic rather than the atherotic component of atherosclerosis. The potential influence of a family history of diabetes on the elastic properties of the aorta needs to be ascertained in further studies.

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“…The Japan Diabetes Complications Study also revealed that, in type 2 diabetic patients, the serum TG, as well as LDL-C, levels were leading predictors of coronary heart disease 44) . For more than two decades, studies have reported a positive relationship between the TG level and atherosclerotic indicators, such as the baPWV [45][46][47] , IMT 48) , forearm blood flow measured with plethysmography 49) , wall thickness measured with echocardiography 50) and flow-mediated dilation (FMD) 51) . In addition, an observational study reported that a decrease in the TG level due to pharmacological therapy was associated with improvement of the baPWV 45) and FMD 51) .…”

Section: Discussionmentioning

confidence: 99%

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

Itô

Satoh‐Asahara

Yamakage

et al. 2014

JAT

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Aim: Previous epidemiological studies demonstrated that the ratio of n-6 to n-3 polyunsaturated fatty acids is associated with cardiovascular diseases. We herein investigated whether the beneficial effect of highly purified eicosapentaenoic acid (EPA) on arterial stiffness is associated with changes in the ratio of polyunsaturated fatty acids, such as EPA, docosahexaenoic acid (DHA) and dihomo-γ-linolenic acid (DGLA), relative to arachidonic acid (AA), in obese Japanese patients with dyslipidemia. Methods: The EPA/AA, DHA/AA and DGLA/AA ratios were compared between obese patients with (n=94) and without (n= 31) dyslipidemia. Among the former group, 88 patients received either highly purified EPA treatment (1.8 g daily, n = 45) or treatment without EPA (control, n = 43). Results: At baseline, the ratios of DHA/AA and DGLA/AA were significantly (P＜0.05) higher in obese patients with dyslipidemia than in those without, while the EPA/AA ratio was similar between patients with and without dyslipidemia. EPA significantly reduced the hemoglobin A1c, total cholesterol, triglycerides, CRP, cardio-ankle vascular index (CAVI) (an index of arterial stiffness) and the DGLA/AA ratio relative to the control at three months after the treatment. On the other hand, EPA significantly increased the adiponectin level and EPA/AA ratio (P＜0.05). A multivariate regression analysis revealed that only age, an increase in the EPA/AA ratio and a decrease in the CRP level were significant determinants of a reduction of the CAVI by EPA. Conclusion: These findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia. J Atheroscler Thromb, 2014; 21:248-260.

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Risk factors for changes in aorto-iliac arterial compliance in healthy men.

Cited by 43 publications

References 10 publications

Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women

Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women

Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia

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