Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study

Abstract

The use of co-amoxiclav for antibiotic prophylaxis in orthopaedic surgery was associated with a decreased rate of post-operative AKI compared with flucloxacillin and gentamicin and was not associated with increased rates of CDI.

Adverse effects of a single dose of gentamicin in adults: a systematic review

“…Thirty‐six studies were included in the final synthesis: one thesis and 35 journal articles . The 36 studies included 11 randomized controlled studies (two crossover designs), 18 cohort studies, one retrospective survey, three pharmacokinetic and three quasiexperimental studies.…”

“…Reported adverse events are summarized in Table . Twenty‐three , of the 36 included studies, reported adverse events in the gentamicin arm of their study although not all adverse events were related to gentamicin. Pons et al .…”

“…A significant number of studies have been published in the last 3 years, almost as many as in the previous 50 years. The majority of these recent studies are a form of cohort study, without randomization.…”

“…The majority of these recent studies are a form of cohort study, without randomization. Many of the studies reviewed a change in local antibiotic policies, particularly within orthopaedic surgery . Authors compared a cephalosporin with gentamicin plus another antibiotic, frequently flucloxacillin.…”

“…Walker et al . presented data from NHS Tayside, orthopaedic department between October 2008 and December 2013, which may also be included in the study by Bell et al . covering five surgical specialities (including orthopaedic surgery) in NHS Tayside between October 2006 and September 2010.…”