This study examined the relationship between smile type and play type during parent-infant interactions in the home. Thirty-six mother-infant and father-infant dyads were videotaped playing for 10 min. Smile type (basic, Duchenne, and duplay smiles) and play type (object, physical, vocal, and book reading) were coded. Results of loglinear analysis indicated that different types of smiles occur during different types of play more often than expected if distributed equally. In addition, different smile-type and play-type patterns occurred for father-infant dyads compared with mother-infant dyads. Qualitative analyses were used to generate hypotheses about the reasons why different types of smiles occurred during various play activities.
Angiogenesis, the formation of new blood vessels, is essential for tumor growth, stabilization and progression. Angiogenesis inhibitors are now widely used in the clinic; however, there are relatively few published studies on the mechanism of their presumed teratogenic effects. To address this issue, we screened a variety of angiogenesis inhibitors in developing zebrafish and chicken embryo models to assess for developmental defects and potential teratogenic effects. We confirmed previous reports that sunitinib, sorafenib and TNP-470 are teratogenic and demonstrate that axitinib, pazopanib, vandetanib, and everolimus are also teratogens in these models. A dose response study identified the drugs inhibit HUVEC cell proliferation in vitro, and also target the developing blood vessels of embryos in vivo. This provides further evidence for the potential risk of fetal toxicity when using these drugs in a clinical setting, and emphasizes the importance of the development and maintenance of the vasculature in the embryo. We conclude that angiogenesis inhibitors, regardless of the molecular target, are teratogenic when exposed to chicken embryos.
Both early interfacility transfer to a cardiac arrest receiving center and direct transport to a cardiac arrest receiving center from the scene are independently associated with reduced mortality.
The Medical Mentorship Programme has been shown to be an effective conduit for supporting the transfer of learning needed to address performance gaps in students. The programme increased the confidence of students in preparation for clinical practice and allowed junior doctors to reflect on their professional development. The programme combined complementary teaching techniques - mentorship, simulation and direct clinical experience - to aid the professional development of both students and mentors. Some new doctors continue to struggle with increased responsibilities.
The discriminability of line segments in a number of different geometric forms was examined. The procedure used was to have one of the lines within a given form drawn thinner than the other lines. The location of the thin line varied randomly within the form, and subjects were required to detect its location. Three observations were made. First, outer line elements were discriminated more accurately than inner line elements. Second, the outer-line advantage appeared to reflect an attentional strategy: By presenting inner and outer lines independently, and informing subjects in advance as to whether target lines would be in the inner or outer area of the form, the outer line advantage could be eliminated. Third, consonant with a global attentional strategy, and in opposition to any retinally tied, peripheral-to-central scanning process, an outer-line advantage was evident regardless of whether the fixation point was positioned within or outside the forms, or whether outer lines were more peripheral than inner lines.
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