Reduction in Midthigh Low-Density Muscle with Aerobic Exercise Training and Weight Loss Impacts Glucose Tolerance in Older Men

Prior, Steven J.; Joseph, Lyndon; Brandauer, Josef; Katzel, Leslie I.; Hagbèrg, James M.; Ryan, Alice S.

doi:10.1210/jc.2006-2113

Cited by 62 publications

(59 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously reported, a reduced attenuation value of skeletal muscle would most likely reflect an increased fat content in the skeletal muscle (Goodpaster et al 1999;Kelley et al 2000;Smith et al 2001) and normal-density muscle area would reflect a lower fat and possibly a healthier muscle. The present finding of endurance exercise training inducing delipidation of skeletal muscle is consistent with previously published studies (Prior et al 2007;Ryan et al 2000Ryan et al , 2006 and may contribute to the beneficial effects of exercise training on glucose-insulin homeostasis and cardiometabolic risk profile (Prior et al 2007). In this regard, the significant association between changes in low-attenuation muscle and changes in VAT volume suggests than such reduction in lowattenuation muscle area in response to an exercise program may represent a CT-imaging marker of ectopic fat mobilization (in this case in the skeletal muscle), which is to be expected from a loss of VAT.…”

Section: Discussionsupporting

confidence: 93%

Interrelationships between changes in anthropometric variables and computed tomography indices of abdominal fat distribution in response to a 1-year physical activity–healthy eating lifestyle modification program in abdominally obese men

Villeneuve

Pelletier-Beaumont

Nazare

et al. 2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

The objectives were to (i) measure the effects of a 1-year lifestyle modification program on body fat distribution/anthropometric variables; (ii) determine the interrelationships between changes in all these variables; and (iii) investigate whether there is a selective reduction in deep (DSAT) vs. superficial subcutaneous adipose tissue (SSAT) at the abdominal level following a 1-year lifestyle modification program. Anthropometric variables, body composition and abdominal and midthigh fat distribution were assessed at baseline and after 1 year in 109 sedentary, dyslipidemic and abdominally obese men. Reductions in anthropometric variables, skinfold thicknesses (except the trunk/extremity ratio) and fat mass as well as an increase in fat-free mass were observed after 1 year (p < 0.0001). Decreases in abdominal adipose tissue volumes were also noted (-23%, -26%, -18%, -19%, -17%, p < 0.0001 for total adipose tissue, visceral adipose tissue, subcutaneous adipose tissue, DSAT and SSAT, respectively). Adipose tissue areas at midthigh also decreased (-18%, -18%, -17%, p < 0.0001 for total, deep, and subcutaneous adipose tissue, respectively). A reduction (-9%, p < 0.0001) in low-attenuation muscle area and an increase (+1%, p < 0.05) in normal-attenuation muscle area were also observed. There was a positive relationship between changes in visceral adipose tissue and changes in DSAT (r = 0.65, p < 0.0001) or SSAT (r = 0.63, p < 0.0001). Although absolute changes in DSAT were greater than changes in SSAT, relative changes in both depots were similar, independent of changes in visceral adipose tissue. The 1-year lifestyle modification program therefore improved the body fat distribution pattern and midthigh muscle quality in abdominally obese men.

show abstract

Section: Discussionsupporting

confidence: 93%

Interrelationships between changes in anthropometric variables and computed tomography indices of abdominal fat distribution in response to a 1-year physical activity–healthy eating lifestyle modification program in abdominally obese men

Villeneuve

Pelletier-Beaumont

Nazare

et al. 2014

Appl. Physiol. Nutr. Metab.

View full text Add to dashboard Cite

show abstract

“…Visceral, subcutaneous, and intermuscular adipose tissue are associated with an increased risk of developing impaired glucose tolerance and insulin sensitivity, which result in the occurrence of type-2 diabetes [26,31] and are directly associated with coronary artery disease [32]. Interestingly, in the present study, the robust subjects showed greater VAT at the L2-L3 and L4-L5 levels compared with frail subjects.…”

Section: Discussionmentioning

confidence: 41%

Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians

Idoate¹,

Cadore

Casas‐Herrero

et al. 2014

Eur Radiol

View full text Add to dashboard Cite

show abstract

“…This small increase might be somewhat misleading as the DASH-RT group signiWcantly increased NDM (i.e., skeletal muscle with low lipid content) while signiWcantly decreasing lipid-rich LDM. Low muscle attenuation represents increased adipose content in and around the muscle Wbers (Goodpaster et al 1997) and has been shown to be a predictor of impaired glucose tolerance and insulin resistance in sedentary older individuals (Prior et al 2007). Surprisingly, there was no change in peak power in the DASH-RT group but there was an increase in muscle power quality and a tendency to increase peak power in the DASH group.…”

Section: Discussionmentioning

confidence: 97%

Effect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults

et al. 2010

View full text Add to dashboard Cite

The impact of resistance training has not been thoroughly examined in overweight older adults undergoing weight loss. Subjects (n = 27) were overweight and obese (BMI 31.7 +/- 3.6 kg/m(2)) older (age 67 +/- 4 years) adults and were randomized into either a 10-week Dietary Approaches to Stop Hypertension for weight loss diet (DASH, n = 12) or DASH plus moderate intensity resistance training (DASH-RT, n = 15). Outcomes included weight loss, total body and mid-thigh composition, muscle and physical function. There were no significant weight loss differences between the DASH-RT and DASH groups (-3.6 +/- 0.8 vs. -2.0 +/- 0.9%, p = 0.137). The DASH-RT group had a greater reduction in body fat than the DASH group (-4.1 +/- 0.9 vs. -0.2 +/- 1.0 kg, p = 0.005). The DASH-RT group had greater changes in lean mass (+0.8 +/- 0.4 vs. -1.4 +/- 0.4 kg, p = 0.002) and strength (+60 +/- 18 vs. -5 +/- 9 N, p = 0.008) than the DASH group. There were favorable changes in mid-thigh composition variables in the DASH-RT group that were different than the lack of changes observed in the DASH group, except for intermuscular adipose tissue. Both groups experienced decreases in 400-m walk times showed (DASH -36 +/- 11 s, DASH-RT -40 +/- 7 s) with no differences between groups. Moderate intensity resistance training during weight loss appears to improve fat mass and thigh composition, but weight loss only does not. However, global measures of physical functioning may improve with a weight loss-only program.

show abstract

Reduction in Midthigh Low-Density Muscle with Aerobic Exercise Training and Weight Loss Impacts Glucose Tolerance in Older Men

Abstract: AEX + WL is more efficacious than AEX for reducing LDM and glucose tolerance. The improvement in glucose tolerance may be partially mediated by decreases in LDM in older men.

Cited by 62 publications

References 37 publications

Interrelationships between changes in anthropometric variables and computed tomography indices of abdominal fat distribution in response to a 1-year physical activity–healthy eating lifestyle modification program in abdominally obese men

Interrelationships between changes in anthropometric variables and computed tomography indices of abdominal fat distribution in response to a 1-year physical activity–healthy eating lifestyle modification program in abdominally obese men

Adipose tissue compartments, muscle mass, muscle fat infiltration, and coronary calcium in institutionalized frail nonagenarians

Effect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults

Contact Info

Product

Resources

About