Reducing the Histopathological and Biochemical Toxicity of Aflatoxins Contaminated Soybean Using Ozone Treatment

Shahat, Mohamed; Badr, Ahmed Noah; Hegaziy, Ahmed; Ramzy, Sherif; Samie, M E El

doi:10.9734/arrb/2017/35075

Cited by 19 publications

(17 citation statements)

References 13 publications

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“…These results were in close relation with Chibanga, et al, (2014) on broiler chicken as they found a reduction in the concentration of serum metabolites including total proteins and albumin. The decrease in serum protein observed might be due to less protein synthesis by injured liver and increased protein loss by injured renal tubules (Benjamin, 1978).These observations agreed by that of Shahat, et al, (2017) who used ozone to reduce the toxicity of aflatoxinscont aminated soybean. Also El-Desouky et al, (2017) studied the use of ozone gas to reduce and /or removal of AFB1.…”

Section: Resultssupporting

confidence: 53%

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Abdelrahman

Ali

Abo-hagger

et al. 2017

Journal of Agricultural Chemistry and Biotechnology

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An experiment was conducted to determine the efficiency of banana peel to reduce the toxic effect of aflatoxins (AFS) in male albino rats. Seventy eight male albino rats were assigned to 13 experimental diets. The first one served as control received basal diet only, the second served as control DMSO (basal diet and 5ml DMSO /kg B.W.) daily, but the third and fourth one were received 1mg and 2mg AFs/ml respectively. The three following groups were received basal diet only supplemented with banana peel in percentage of 1,2 and 3%,then three groups received basal diet and orally (1mg AFS suspended in 5ml DMSO /kg B.W.) low dose of aflatoxins with the same levels of banana peel. The last three groups received basal diet and orally (2mg AFS suspended in 5ml DMSO /kg B.W.) high dose of aflatoxins with the same levels of banana peel .The duration of this experiment was 6 weeks. Results showed that, albino rats received 38mg and 76mg/kg aflatoxins revealed a significant elevation in the serum levels of AST, ALT, ALP, creatinine, urea, cholesterol and triglyceride, while decrease in total protein (TP) and albumin. Results of hematological parameters showed decrease in red blood cells (RBCs), hemoglobin (HB), packed cell volume (PCV), mean Corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) and platelets while increase in total leucocyte count (TLC).Body weights and organ weights were determined to study its changes. The treatments with banana peel can play a practical role in detoxification of aflatoxins in albino rats. G3Received orally low dose of AF S (1mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G4 Received orally high dose of AF S (2mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G5 Received basal diet supplemented with banana peel at level 1% G6 Received basal diet supplemented with banana peel at level 2% G7 Received basal diet supplemented with banana peel at level 3% G8 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G9 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G10 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel G11 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G12 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G13 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel

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Section: Resultssupporting

confidence: 53%

Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Abdelrahman

Ali

Abo-hagger

et al. 2017

Journal of Agricultural Chemistry and Biotechnology

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“…Aflatoxins, particularly AFB 1 , are a major risk counter the healthful parameters and causing several issues for humans and animals. Because of the consideration that AFB 1 is pre-carcinogenic compound [16], also it was found excreting by toxigenic fungi on food commodities [18,23] at several stages (pre-harvest; post-harvest; transportation; storage; handling). In this respect, a need for novel strategies avoiding mycotoxin health hazard of contaminated diets is requesting.…”

Section: Resultsmentioning

confidence: 99%

“…Aflatoxins (AFs) are exceedingly the highest hazardous health' enemies for human and animal, it can cause mutagenicity and carcinogenesis effects through feed and food contamination [[16], [17], [18]]. Many food materials contaminated by toxigenic fungi [[19], [20], [21]], which rise mycotoxin-excretion on food commodities [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Many food materials contaminated by toxigenic fungi [[19], [20], [21]], which rise mycotoxin-excretion on food commodities [22,23]. In comparison to other contaminants, AFs are a great source to chronic diseases exposure like cancers particularly aflatoxin B 1 (AFB 1 ), related to mycotoxin presence in body fluids [16,[24], [25], [26]]. The present study aims to clarify the potential impact of CGB as anticancer agent against aflatoxin G 1 (AFG 1 ) and clear its ability to reduce the proportion of pre-carcinogenic compound represented by AFs in light of the bioactive substances involved in this plant.…”

Section: Introductionmentioning

confidence: 99%

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Protective efficacy using Cape- golden berry against pre-carcinogenic aflatoxins induced in rats

Badr

Naeem

2019

Toxicology Reports

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“…Yılmaz et al (2017) recommended that vitamin E can be regarded as a good therapeutic agent against aflatoxicosis. Shahat et al (2017) found damage effects of aflatoxins in liver and kidney tissues so they used ozone to reduce this effect.…”

Section: G1mentioning

confidence: 99%