Reducing the Consumption of Antibiotics: Would That Be Enough to Slow Down the Dissemination of Resistances in the Downstream Environment?

Merlin, Christophe

doi:10.3389/fmicb.2020.00033

Cited by 32 publications

(22 citation statements)

References 20 publications

(22 reference statements)

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“…Furthermore, antibiotic use enriches antibiotic resistant bacteria or resistance genes, which could be transferred from the environment to humans. It is assumed that increased antibiotic consumption may cause failure of treatments in human medicine (infections caused by antibiotic resistant bacteria), increasing duration of illness, morbidity and mortality [18][19][20][21].…”

Section: Antibiotic Consumption and Antibiotics Occurrence Into The Ementioning

confidence: 99%

Antibiotics in the environment: causes and consequences

Polianciuc

Gurzău²,

Kiss

et al. 2020

Medicine and Pharmacy Reports

209

173

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Antibiotics represent one of the main discoveries of the last century that changed the treatment of a large array of infections in a significant way. However, increased consumption has led to an exposure of bacterial communities and ecosystems to a large amount of antibiotic residues. This paper aims to provide a brief overview of the primary drivers associated with antibiotic occurrence in the environment. Furthermore, we attempted to summarize the behavior of antibiotic residues in the environment and the necessity of their detection and quantification. Also, we provide updated scientific and regulatory facts about environmental antibiotic discharge and environmental and human antibiotics risk assessment. We propose that environmental antibiotic contamination should be diminished beginning from regulating the causes of occurrence in the environment (such as antibiotic consumption) and ending with regulating antibiotic discharge and risk assessment. Some important intermediate steps are represented by the detection and quantification of the antibiotics and the characterization of their behavior in the environment, which could come to support future regulatory decisions.

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Section: Antibiotic Consumption and Antibiotics Occurrence Into The Ementioning

confidence: 99%

Antibiotics in the environment: causes and consequences

Polianciuc

Gurzău²,

Kiss

et al. 2020

Medicine and Pharmacy Reports

209

173

View full text Add to dashboard Cite

show abstract

“…Another explanation could be the collateral effect of antibiotics, which means that not only subinhibitory concentrations of an antibiotic could stimulate the emergence and the dissemination of its corresponding resistant gene, but that collateral stimulation by other antibiotics is also possible. For example, the mobile genetic element carrying the gene for tetracycline resistance is able to exhibit a 1000-fold increase of its transfer frequency when exposed to subinhibitory concentrations of tetracyclines, but also macrolides, lincosamides and streptogramins [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Implementation of Antibiotic Stewardship in a University Hospital Setting

et al. 2021

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The article describes activities of an antibiotic center at a university hospital in the Czech Republic and presents the results of antibiotic stewardship program implementation over a period of 10 years. It provides data on the development of resistance of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus to selected antibiotic agents as well as consumption data for various antibiotic classes. The genetic basis of resistance to beta-lactam antibiotics and its clonal spread were also assessed. The study showed significant correlations between aminoglycoside consumption and resistance of Escherichia coli and Klebsiella pneumoniae to gentamicin (r = 0.712, r = 0.869), fluoroquinolone consumption and resistance of Klebsiella pneumoniae to ciprofloxacin (r = 0.896), aminoglycoside consumption and resistance of Pseudomonas aeruginosa to amikacin (r = 0.716), as well as carbapenem consumption and resistance of Pseudomonas aeruginosa to meropenem (r = 0.855). Genotyping of ESBL- positive isolates of Klebsiella pneumoniae and Escherichia coli showed a predominance of CTX-M-type; in AmpC-positive strains, DHA, EBC and CIT enzymes prevailed. Of 19 meropenem-resistant strains of Klebsiella pneumoniae, two were identified as NDM-positive. Clonal spread of these strains was not detected. The results suggest that comprehensive antibiotic stewardship implementation in a healthcare facility may help to maintain the effectiveness of antibiotics against bacterial pathogens. Particularly beneficial is the work of clinical microbiologists who, among other things, approve administration of antibiotics to patients with bacterial infections and directly participate in their antibiotic therapy.

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“…Consequently, antibiotic residues re-enter the hydrogeological cycle after the treatment at concentrations ranging from a few tens to hundreds of nanograms per liter [ 2 , 3 , 4 , 5 ]. These low concentrations are, however, high enough to cause well-known collateral effects, such as the generation of antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARG) [ 1 , 6 ]. It has been recently reported that reducing antibiotics consumption would not be enough to slow down the dissemination of resistance [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…These low concentrations are, however, high enough to cause well-known collateral effects, such as the generation of antibiotic-resistant bacteria (ARB) and antibiotic-resistant genes (ARG) [ 1 , 6 ]. It has been recently reported that reducing antibiotics consumption would not be enough to slow down the dissemination of resistance [ 6 ]. For this reason, the recent EU directive (2015/495/EU) has been updated (2018/840/EU), both to implement the current legislation and provide new proposals, such as the “action plan against the rising threats from antimicrobial resistance” specifically intended to regularly monitor antibiotics and, as well as, to reduce their widespread distribution [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc Based Metal-Organic Frameworks as Ofloxacin Adsorbents in Polluted Waters: ZIF-8 vs. Zn3(BTC)2

Capsoni

Guerra

Puscalau

et al. 2021

IJERPH

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Two different zinc-based metal-organic frameworks (MOFs) were investigated to remove one of the most used fluoroquinolone antibiotic, Ofloxacin (OFL), from polluted water. The most common zeolitic imidazolate framework-8 (ZIF-8) and the green Zn(II) and benzene-1,3,5-tri-carboxylate (Zn3(BTC)2) were prepared through a facile synthetic route and characterized by means of Fourier-Transform Infrared (FT-IR) Spectroscopy, X-ray Powder Diffraction (XRPD), and Scanning Electron Microscopy (SEM) analyses. The two MOFs were compared in terms of both adsorption and kinetic aspects under real conditions (tap water, natural pH). Results showed that OFL was adsorbed in remarkable amounts, 95 ± 10 and 25.3 ± 0.8 mg g−1 on ZIF-8 and Zn3(BTC)2, respectively, following different mechanisms. Specifically, a Langmuir model well described the ZIF-8 profile, while for Zn3(BTC)2, cooperative adsorption occurred. Moreover the kinetic results were quite different, pseudo-second-order and sigmoidal, respectively. The suitability of ZIF-8 and Zn3(BTC)2 as adsorbent phases for water depollution was tested on tap water samples spiked with OFL 10 µg L−1. The obtained removal efficiencies, of 88% for ZIF-8 and 72% for Zn3(BTC)2, make these materials promising candidates for removing fluoroquinolone antibiotics (FQs) from polluted waters, notwithstanding their limited reusability in tap water, as demonstrated by in-depth characterization of the two MOFs after usage.

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Reducing the Consumption of Antibiotics: Would That Be Enough to Slow Down the Dissemination of Resistances in the Downstream Environment?

Cited by 32 publications

References 20 publications

Antibiotics in the environment: causes and consequences

Antibiotics in the environment: causes and consequences

Implementation of Antibiotic Stewardship in a University Hospital Setting

Zinc Based Metal-Organic Frameworks as Ofloxacin Adsorbents in Polluted Waters: ZIF-8 vs. Zn3(BTC)2

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