Reducing relapse and accelerating osteogenesis in rapid maxillary expansion using an injectable mesoporous bioactive glass/fibrin glue composite hydrogel
“…to enhance mechanical properties, tensile strength, and osteogenic properties in composite scaffolds. [51][52][53][54][55] Studies have confirmed that BG containing FG can promote cell adhesion and osteogenesis, 56 and a MBG/ FG composite hydrogel can promote osteogenesis in the expanded palate by in situ injection. 52 In this study, exogenous fibrin was readded to coat the CGF/MBG composite scaffold, which could protect the active factors inside from rapid decomposition and extend the effective concentration.…”
Section: In Situ Bone Regeneration Of Cgf/mbg Composite Scaffoldmentioning
confidence: 94%
“…Though freeze-drying is considered a traditional compositing method for bioactive substanceloaded scaffolds, it is indicated in this study that the bioactivity of growth factors in gpCGF might be compromised by the freeze-drying process. In contrast, fibrin gel is also commonly applied in the field of bone regeneration mixed with bone replacement materials for its potential osteogenic induction ability, 52,56,84 and the concentration of thrombin also has been reported in relation to the activity of osteogenesis. 84 Additionally, fibrin gel can protect growth factors from degradation and sustainably release growth factors to achieve superior osteogenic effects, which is similar to the function of the fibrin networks in gpCGF.…”
Maxillofacial bone defect repair and regeneration remains a tremendous challenge in the field of stomatology. However, the limited osteoinductivity of artificial materials and the high cost of bioactive agents restrain...
“…to enhance mechanical properties, tensile strength, and osteogenic properties in composite scaffolds. [51][52][53][54][55] Studies have confirmed that BG containing FG can promote cell adhesion and osteogenesis, 56 and a MBG/ FG composite hydrogel can promote osteogenesis in the expanded palate by in situ injection. 52 In this study, exogenous fibrin was readded to coat the CGF/MBG composite scaffold, which could protect the active factors inside from rapid decomposition and extend the effective concentration.…”
Section: In Situ Bone Regeneration Of Cgf/mbg Composite Scaffoldmentioning
confidence: 94%
“…Though freeze-drying is considered a traditional compositing method for bioactive substanceloaded scaffolds, it is indicated in this study that the bioactivity of growth factors in gpCGF might be compromised by the freeze-drying process. In contrast, fibrin gel is also commonly applied in the field of bone regeneration mixed with bone replacement materials for its potential osteogenic induction ability, 52,56,84 and the concentration of thrombin also has been reported in relation to the activity of osteogenesis. 84 Additionally, fibrin gel can protect growth factors from degradation and sustainably release growth factors to achieve superior osteogenic effects, which is similar to the function of the fibrin networks in gpCGF.…”
Maxillofacial bone defect repair and regeneration remains a tremendous challenge in the field of stomatology. However, the limited osteoinductivity of artificial materials and the high cost of bioactive agents restrain...
“…[173] Fibrin-mesoporous bioactive glass scaffold of Zhao exhibited outstanding osteogenesis, mineralization, and angiogenesis performance while inhibiting osteoclastogenesis due to the calcium and silicate ions. [174] Moncion et al introduced the ultrasound-responsive perfluorocarbon agent to the fibrin to create an acoustic-responsive scaffold. This scaffold showed controllable release property within a week but requires low ultrasound amplitude to avoid cell damage.…”
Bone grafting, as the current gold-standard for large scaled bone damage of various causes, has faced challenges from both the source and appliance. Emerging new tissue engineering substitutes are demonstrating more options and possibilities, with their improved biocompatibility, accessibility, and customizable function. Amongst them, injectable gels (IGs) are a class of gel material displaying astonishing non-invasive properties and surgical viability. While possessing responsiveness toward specific stimuli, they change their physical form in vivo, thus serving as wonderful biomaterials and drug delivery systems. In this review, the mechanics of stimuli-responsive IGs developed during the past decade are illustrated. Two branches of crosslinked gels -co-valent and non-covalent crosslinked IGs and their composition and customization are introduced. In conclusion, the present trend in bone tissue engineering research is summarized and made an outlook for future. It is hoped that this comprehensive review can provide a proper reference for the development of new IGs.
“…Furthermore, the addition of 1 wt% mesoporous bioactive glass significantly enhanced the mechanical strength, matched the degradation rate and ionic dissolution of composite hydrogels, and exhibited excellent biocompatibility and osteoinductivity in vitro while remarkably promoting bone formation and inhibiting osteoclastogenesis in vivo [ 133 ]. Mesoporous materials can also be used as drug carriers in composite hydrogels to load and release various bioactivators to promote osteogenesis.…”
Section: Application Of Mesoporous Material-loaded Composite Hydrogelsmentioning
Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.
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