Optimization of a concentrated growth factor/mesoporous bioactive glass composite scaffold and its application in rabbit mandible defect regeneration

Ma, Min; Shen, Wenbiao; Li, Beibei; Sun, Mengwen; Lin, Da Jun; Meng, Lingqiang

doi:10.1039/d3bm00805c

Cited by 4 publications

(3 citation statements)

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“…New composites have been developed in recent years which exhibit combined properties of individual components and can adapt to the complex maxillofacial structure. 92–94 These materials can achieve both anti-infectious and osteogenic functions simultaneously. Organic/inorganic complexes are among the most commonly used composite materials for this purpose, providing a promising solution for infectious bone defects in the maxillofacial region.…”

Section: Artificial Biomaterialsmentioning

confidence: 99%

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Han,

Xiong,

Jin

et al. 2024

J. Mater. Chem. B

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Section: Artificial Biomaterialsmentioning

confidence: 99%

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Han,

Xiong,

Jin

et al. 2024

J. Mater. Chem. B

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“…This fosters an environment conducive to bone regeneration. Additionally, with its unique flowability and injectability, LPCGF can be integrated with other tissue engineering materials. − This highlights its remarkable biocompatibility and carrier capabilities. Essentially, the distinctive composition and biological characteristics of LPCGF make it a formidable candidate for a bioscaffold in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration Facilitated by Autologous Bioscaffold Material: Liquid Phase of Concentrated Growth Factor with Dental Follicle Stem Cell Loading

Li,

Wang,

et al. 2024

ACS Biomater. Sci. Eng.

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The application of bioengineering techniques for achieving bone regeneration in the oral environment is an increasingly prominent field. However, the clinical use of synthetic materials carries certain risks. The liquid phase of concentrated growth factor (LPCGF), as a biologically derived material, exhibits superior biocompatibility. In this study, LPCGF was employed as a tissue engineering scaffold, hosting dental follicle cells (DFCs) to facilitate bone regeneration. Both in vivo and in vitro experimental results demonstrate that this platform significantly enhances the expression of osteogenic markers in DFCs, such as alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), and type I collagen (Col1a1). Simultaneously, it reduces the expression of inflammation-related genes, particularly interleukin-6 (IL-6) and interleukin-8 (IL-8), thereby alleviating the negative impact of the inflammatory microenvironment on DFCs. Further investigation into potential mechanisms reveals that this process is regulated over time by the WNT pathway. Our research results demonstrate that LPCGF, with its favorable physical characteristics, holds great potential as a scaffold. It can effectively carry DFCs, thereby providing an optimal initial environment for bone regeneration. Furthermore, LPCGF endeavors to closely mimic the mechanisms of bone healing post-trauma to facilitate bone formation. This offers new perspectives and insights into bone regeneration engineering.

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“…To fabricate bone tissue engineering scaffolds, mesoporous bioactive glass (MBG) has gained much attention due to its abilities of high drug loading and inducing bone-like apatite deposition ( Zhu et al, 2015b ; Feng et al, 2023 ; Yang et al, 2023 ). Furthermore, combining MBG with biodegradable polymers to form composite scaffolds can enhance mechanical strength and regulate biological properties of the scaffolds ( Atkinson et al, 2022 ; Shi et al, 2022 ; Atkinson et al, 2023 ; Ma et al, 2023 ; Sanchez-Salcedo et al, 2023 ). For example, Wu et al demonstrated the enhanced osteogenic ability and mechanical strength by loading dexamethasone into the 3D printed MBG scaffolds with poly(vinyl alcohol) as a binder ( Wu et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Dimethyloxallyl glycine-loaded mesoporous bioactive glass/poly(D,L-lactide) composite scaffolds with ultrasound stimulation for promoting bone repair

Han,

Zhao,

Zhu

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Bone tissue engineering is considered the ideal approach for bone repair. Mesoporous bioactive glass (MBG) possesses the characteristics of high drug-loading capacity and bioactivity. Low-intensity pulsed ultrasound contributes to promoting fracture healing and bone defect repair, and dimethyloxalyl glycine (DMOG) is a small molecular inhibitor that can suppress prolyl hydroxylase, reducing the degradation of hypoxia-inducible factor.Methods: In this study, we proposed to prepare DMOG-loaded MBG/poly(D,L-lactide) composite scaffolds (DMOG-MBG/PDLLA) for promoting bone repair. The effects of ultrasound stimulation and DMOG release on the cell responses of rat bone marrow mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs) and bone repair in vivo were investigated.Results and Discussion: The results showed that both ultrasound stimulation and DMOG release could promote the proliferation, adhesion and differentiation of BMSCs and HUVECs, respectively. After the implantation of scaffolds in rat cranial bone defect model for 8 weeks, the results indicated that the combined ultrasound stimulation and DMOG release contributed to the highest ability for promoting bone repair. Hence, the DMOG-MBG/PDLLA scaffolds with ultrasound stimulation are promising for application in bone repair.

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Optimization of a concentrated growth factor/mesoporous bioactive glass composite scaffold and its application in rabbit mandible defect regeneration

Abstract: Maxillofacial bone defect repair and regeneration remains a tremendous challenge in the field of stomatology. However, the limited osteoinductivity of artificial materials and the high cost of bioactive agents restrain...

Cited by 4 publications

References 84 publications

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

Bone Regeneration Facilitated by Autologous Bioscaffold Material: Liquid Phase of Concentrated Growth Factor with Dental Follicle Stem Cell Loading

Dimethyloxallyl glycine-loaded mesoporous bioactive glass/poly(D,L-lactide) composite scaffolds with ultrasound stimulation for promoting bone repair

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