Reducing pill burden and helping with medication awareness to improve adherence

Farrell, Barbara; Merkley, Véronique French; Ingar, Nafisa

doi:10.1177/1715163513500208

Cited by 57 publications

(48 citation statements)

References 12 publications

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“…Pill burden is defined as the total number of pills (tablets or capsules) that a patient takes on a daily basis . It has been shown that a high pill burden negatively affects treatment adherence . The same goes for topical treatments; however, there is no established term to describe how many creams or ointments a patient applies per day.…”

Section: Factors Influencing Treatment Adherencementioning

confidence: 99%

“…65,66 It has been shown that a high pill burden negatively affects treatment adherence. [66][67][68][69] The same goes for topical treatments; however, there is no established term to describe how many creams or ointments a patient applies per day. In a MEMS-controlled acne study, a once daily combination product showed better adherence rates and better efficacy than daily application of the same two pharmacological agents separately.…”

Section: Treatment-relatedmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease – strategies for optimizing treatment outcome

Eicher

Knop

Aszodi

et al. 2019

Acad Dermatol Venereol

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Adherence describes how a patient follows a medical regime recommended by a healthcare provider. Poor treatment adherence represents a complex and challenging problem of international healthcare systems, as it has a substantial impact on clinical outcomes and patient safety and constitutes an important financial burden. Since it is one of the most common causes of treatment failure, it is extremely important for physicians to reliably distinguish between non‐adherence and non‐response. This systematic review aims to summarize the current literature on treatment adherence in dermatology, focusing on chronic inflammatory skin diseases such as psoriasis, atopic dermatitis and acne. A systematic literature search was performed using the PubMed Database, including articles from 2008 to 2018. Low treatment adherence is a multidimensional phenomenon defined by the interplay of numerous factors and should under no circumstances be considered as the patient's fault alone. Factors influencing treatment adherence in dermatology include patient characteristics and beliefs, treatment efficacy and duration, administration routes, disease chronicity and the disease itself. Moreover, the quality of the physician‐patient relationship including physician‐time available for the patient plays an important role. Understanding patients’ adherence patterns and the main drivers of non‐adherence creates opportunities to improve adherence in the future. Strategies to increase treatment adherence range from reminder programs to simplifying prescriptions or educational interventions. Absolute adherence to treatment may not be realistically achievable, but efforts need to be made to raise awareness in order to maximize adherence as far as possible.

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Section: Factors Influencing Treatment Adherencementioning

confidence: 99%

Section: Treatment-relatedmentioning

confidence: 99%

A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease – strategies for optimizing treatment outcome

Eicher

Knop

Aszodi

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Breslow [25] 2013 U USA Community Pharmacy 26 Fountain [55] 2007 U USA Community Pharmacy 1 Manrai [26] 2015 U c UK Community Pharmacy ? U Rickles [24] 2008 U USA Community Pharmacy 161 Gustafsson [56] 2012 U Sweden Geriatric care unit 895 Child [30] 2011 U UK GP Surgery 70 Stuhec [57] 2013 U Slovenia GP Surgery 629 U Efjestad [58] 2011 U Norway Hospital (all) 50 Farrell [59] 2013 U Canada Hospital Inpatient 1 Frausto [60] 2013-14 U USA Hospital Inpatient 128 Mouchoux [61] 2011 U France Hospital Inpatient 97 Paquin [62] 2010-12 U USA Hospital Outpatient 501 Watanabe [21] 2008-12 U Japan Hospital Outpatient 111 D'Souza [63] 2010-12 U USA Medical centre 162 Cations [64] 2015 U Australia Residential aged care facility 81 U there being insufficient high-quality evidence to supporting the development of future community pharmacy interventions. The most common countries to have conducted the research were the UK and the USA, and the most common forms of intervention involved a medicine review or the provision of support to either a PWD or their carer.…”

Section: Discussionmentioning

confidence: 99%

Systematic review to inform the development of a community pharmacy-based intervention for people affected by dementia

Dann-Reed

Poland

Wright

2019

International Journal of Pharmacy Practice

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Objectives People living with dementia (PWD) frequently receive medicine regularly from their community pharmacy, thus providing an opportunity to address either directly or through a carer any unmet medicine-related needs. The aim of this systematic review was to identify, describe, and evaluate the quality of the research for dementia-specific pharmacy-based interventions with potential for delivery through community pharmacy. This would inform the design of future services and associated trials. Key Findings The systematic review process identified 29 studies. Interventions were categorised as medication review, targeted medicine intervention, education, memory screening and miscellaneous. Five studies were set in community pharmacy. Interventions frequently targeted antipsychotics, benzodiazepines and anticholinergic medication. Twenty interventions were medicine-related. Eighteen studies were categorised as 'very low' quality, often due to small sample size. Summary The review identified a range of interventions, which could be delivered through community pharmacy, and potentially benefit PWD. Developing appropriate and efficient training and working in multi-disciplinary teams were identified as necessary for effectiveness. Further research is needed to identify which service elements are likely to be acceptable to both patients and practitioners as well as the barriers and enablers to their implementation.

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“…Therefore, a single-pill or fixed-dose combination therapy is often preferred to reduce the polypharmacy burden and improve patients' compliance [37, 38]. A number of workers have employed AD in combination with other drugs as a single-pill and used it clinically with reasonable success.…”

Section: Formulations Of Admentioning

confidence: 99%

Formulations of Amlodipine: A Review

Sheraz

Ahsan

Khan

et al. 2016

Journal of Pharmaceutics

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Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light. A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. This review highlights all the formulations that have been developed to achieve maximum stability with the desired therapeutic action for the delivery of AD such as fast dissolving tablets, floating tablets, layered tablets, single-pill combinations, capsules, oral and transdermal films, suspensions, emulsions, mucoadhesive microspheres, gels, transdermal patches, and liposomal formulations.

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Reducing pill burden and helping with medication awareness to improve adherence

Cited by 57 publications

References 12 publications

A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease – strategies for optimizing treatment outcome

A systematic review of factors influencing treatment adherence in chronic inflammatory skin disease – strategies for optimizing treatment outcome

Systematic review to inform the development of a community pharmacy-based intervention for people affected by dementia

Formulations of Amlodipine: A Review

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