“…Midazolam, a benzodiazepine that provides amnesia, muscle relaxation and anxiolysis, was shown to be better than placebo for procedural sedation 1 2. However, the reported efficacy of oral midazolam is only 60–76%,1 3 meaning, that up to 40% of children who were treated with midazolam alone, stayed awake and active, and required intravenous sedation or the use of restraining techniques.…”