A double-blind, randomised, placebo-controlled trial of oral midazolam plus oral ketamine for sedation of children during laceration repair

Abstract

Objectives To compare the efficacy of oral midazolam alone with a combination of oral midazolam and ketamine in children requiring laceration repair.

A rectally administered combination of midazolam and ketamine was easy, effective and feasible for procedural pain in children with cerebral palsy

“…According to Chow et al (5) and our results, midazolam in combination with ketamine might be a safe alternative. Our results were in accordance with other studies where orally administered midazolam and ketamine were used in other settings like bone marrow aspiration (28) and laceration repair (29). Gubbay et al (30) reported in a letter to the editor that intranasal fentanyl was usually good enough and better than just midazolam.…”

Oral Midazolam and Ketamine as Premedicants in Children- A Randomized Open Label Single Centre Study

“…The level of sedation score>3 was achieved similarly in both the groups at 45minutes.Studies have shown that achieving adequate sedation was more common in children treated with the combination of ketamine and midazolam rather than oral midazolam alone. [6,7,8] Procedural sedation was adequately achieved with fentanyl and midazolam combination in one study. [9] Separation from parents was equally good in both groups however anxiolysis on venepuncture was poor in 28% and 34% cases with midazolam and ketamine respectively.…”

Ketamine and midazolam as procedural sedation in children : a structured literature review and narrative synthesis

“…4 Numerous studies evaluating this combination have been conducted. [4][5][6][7][8][9][10] The authors sought to conduct a structured literature review and narrative synthesis to determine the efficacy and possible adverse effects of this combination when used as a premedication in paediatric patients undergoing elective surgery compared with midazolam alone as a premedication.…”