Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder

Lo, Yu Chun; Chen, Yu-Jen; Hsu, Ying Shao; Tseng, Wen‐Yih Isaac; Gau, Susan Shur‐Fen

doi:10.1111/jcpp.12641

Cited by 35 publications

(35 citation statements)

References 64 publications

(91 reference statements)

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“…Alteration of the FAT was also found in boys with ASD [Lo et al, ]. Consistent with previous reports, the present study found that the boys with ASD showed significantly reduced GFA values in the SLF III, AF, and FAT, compared with the siblings of individuals with ASD and TD boys [Amaral et al, ; Anagnostou & Taylor, ; Barnea‐Goraly & Hardan, ; Fletcher et al, ; Groen et al, ; Lo et al, ; Poustka et al, ; Shukla et al, ]. Our results imply that the altered tract integrity of these tracts might be associated with the social communication deficits of ASD.…”

Section: Discussionsupporting

confidence: 91%

“…The SMA that connects the IFG via the FAT has been associated with the impaired language and communication characteristics of ASD [Amaral, Schumann, & Nordahl, 2008]. Alteration of the FAT was also found in boys with ASD [Lo et al, 2017]. Consistent with previous reports, the present Table 3.…”

Section: Discussionsupporting

confidence: 89%

“…SLF impairment has been reported elsewhere in ASD studies [Naigles et al, ; Poustka et al, ], and is associated with the severity of autism symptoms [Blanken et al, ; Ingalhalikar, Parker, Bloy, Roberts, & Verma, ]. Conversely, FAT impairment in individuals with ASD has been associated with social interaction deficits [Lo et al, ] and difficulties with speech initiation and fluency [Chenausky, Kernbach, Norton, & Schlaug, ]. According to the elaboration on the five‐level model for social communication by Catani and Bambini [], the SLF III initiates informative actions, which are the first steps of social interaction.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with previous reports, the present Table 3. Partial Correlation Between the Averaged Generalized Fractional Anisotropy Values at Each Level of the Social Communication Models and the Social Communication and Social Problems Scores of the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL), Respectively, for the Three Groups study found that the boys with ASD showed significantly reduced GFA values in the SLF III, AF, and FAT, compared with the siblings of individuals with ASD and TD boys [Amaral et al, 2008;Anagnostou & Taylor, 2011;Barnea-Goraly & Hardan, 2011;Fletcher et al, 2010;Groen et al, 2011;Lo et al, 2017;Poustka et al, 2012;Shukla et al, 2010]. Our results imply that the altered tract integrity of these tracts might be associated with the social communication deficits of ASD.…”

Section: Discussionmentioning

confidence: 99%

“…This hierarchical model provides a clear concept to link white matter tracts to the function of social communication in healthy populations and allows focused investigation of these white matter tracts and their associations with social communication deficits of ASD. Our previous study on the basis of the social communication model revealed reduced tract integrity of the SLF III and FAT, and their associations with the social interaction deficits, implying that these two tracts might be the neural substrates of social communication deficits in ASD [Lo, Chen, Hsu, Tseng, & Gau, ].…”

Section: Introductionmentioning

confidence: 99%

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Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract‐based automatic analysis

Chen

Hsu

et al. 2018

Autism Research

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Investigating social behaviors and brain structural alterations in unaffected siblings of individuals with autism spectrum disorder (ASD) may help identify intermediate phenotypes of social communication deficits in ASD. This study hypothesized that such intermediate phenotypes could be identified in white matter tracts of the social communication model that exhibited reduced tract integrity and associations with social communication deficits. Boys with ASD (N = 30), unaffected male siblings (N = 27), and typically developing (TD) boys (N = 30) underwent clinical evaluation and MRI scanning. Group differences in generalized fractional anisotropy (GFA) values, a white matter integrity index derived from diffusion MRI data, and the relationships of GFA with the Social Responsiveness Scale (SRS) scores and the Child Behavior Checklist (CBCL/4–18) scores were investigated. Significant differences were found in the GFA values of the frontal aslant tract (FAT) among the three groups, with the decreasing order of GFA from TD to siblings to ASD. The GFA values of the FAT were associated with the social communication scores (on the SRS) in the sibling group, and those of the superior longitudinal fasciculus III were associated with the social problems scores (on the CBCL/4–18) in the boys with ASD. Due to the altered tract integrity and association with social communication deficits in the unaffected siblings of individuals with ASD, the FAT might be a heritable neural basis for social communication deficits of ASD. Autism Res 2019, 12: 225–238 © 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism spectrum disorder (ASD) is a group of highly heritable disorders with social communication deficits as one of the core symptoms. This study aimed to identify a neural trait of social communication deficits in individuals with ASD. We investigated brain structural alterations and their associations with social communication scores in unaffected siblings of individuals with ASD. The siblings' frontal aslant tract was found to be impaired, and this tract showed a significant association with the social communication scores. Our findings support that the frontal aslant tract might be a potential neural trait of social communication deficits in ASD.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract‐based automatic analysis

Chen

Hsu

et al. 2018

Autism Research

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School dysfunction in youth with autistic spectrum disorder in Taiwan: The effect of subtype and ADHD

et al. 2018

Self Cite

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Impaired school functions varied in ASD youths with different characteristics. Youths with autism spectrum disorder (ASD) encounter varying levels and domains of impaired performance at schools, such as lower academic performance, negative attitude toward school work, fewer reciprocal friendships, and more behavioral problems. Our results indicate that ASD youths without intellectual disability had better academic performance, but worse attitude toward school than those with intellectual disability. Co-occurrence with ADHD is associated with school dysfunction. In summary, intelligence and comorbid ADHD influences several domains of school functions.

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White and gray matter correlates of theory of mind in autism: a voxel-based morphometry study

2023

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Autism spectrum disorder (ASD) is characterized by difficulties in theory of mind (ToM) and social communication. Studying structural and functional correlates of ToM in the brain, and how autistic and nonautistic groups differ in terms of these correlates can help with diagnosis and understanding biological mechanisms of ASD. In this study, we investigated white matter volume (WMV) and gray matter volume (WMV) differences between matching autistic and nonautistic samples, and how these structural features relate to age and theory of mind (ToM) skills, indexed by the Reading the Mind in the Eyes (RMIE) measure. The results showed widespread GMV and WMV differences between the two groups in regions crucial for social processes. The autistic group did not express the typically observed negative GMV and positive WMV correlations with age at the same level as the nonautistic group, pointing to abnormalities in developmental structural changes. In addition, we found differences between the two groups in how GMV relates to ToM, particularly in left frontal regions, and how WMV relates to ToM, mostly in the cingulate and corpus callosum. Finally, GMV in left insula, a region that is part of the salience network, was found to be crucial in distinguishing ToM performance between the two groups.

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Reduced tract integrity of the model for social communication is a neural substrate of social communication deficits in autism spectrum disorder

Cited by 35 publications

References 64 publications

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract‐based automatic analysis

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract‐based automatic analysis

School dysfunction in youth with autistic spectrum disorder in Taiwan: The effect of subtype and ADHD

White and gray matter correlates of theory of mind in autism: a voxel-based morphometry study

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