Reduced testosterone and adrenal C19 steroid levels in obese men

Tchernof, André; Després, Jean‐Pierre; Bélanger, Alain; Dupont, André; Prud’homme, Denis; Moorjani, Sital; Lupien, Paul J.; Labrie, Fernand

doi:10.1016/0026-0495(95)90060-8

Cited by 168 publications

(141 citation statements)

References 32 publications

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“…15 The decrease in androgen levels is proportional to the degree of obesity. 16,17 The results of our study are in line with all this evidence because the prevalence of obesity was lower in the PE group than the control group.…”

Section: Discussionsupporting

confidence: 90%

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Gökçe

Ekmekçioğlu

2010

Int J Impot Res

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Although both biological and psychological factors are important in the etiology, the exact pathogenesis of lifelong premature ejaculation (PE) remains to be clarified. Obesity is a worldwide epidemic that contributes to many chronic diseases. Obesity is associated with erectile dysfunction, but the relationship between obesity and PE has not yet been specifically investigated. The aim of this study was to evaluate the relationships of these two conditions. Between January 2008 and December 2009, we evaluated consecutive patients with lifelong PE in the urology outpatient clinic. Control cases without lifelong PE were selected randomly among cases attending the department of internal medicine for a checkup procedure. The age and sex of control group were matched with that of the study group. Body mass index (BMI) of each case was calculated using the World Health Organization criteria by the measurements of the physician instead of relying on verbal expressions. The mean (±s.d.) age of the premature ejaculators was 31.7±5.7 (range 21-51) years and in the control cases it was 32.3±6.7 (range 22-54) years. The comparison of the mean (±s.d.) weight between the study (74.1 ± 11.2 kg) and control groups (81.9 ± 6.4 kg) revealed a significant difference (Po0.001). The mean BMI of premature ejaculators (24.9 ± 3.4 kg m -2 ) was lower than the mean BMI of control (27.5±3.6 kg m -2 ; Po0.001). As the BMI increased, the number of patients decreased in the PE group. The number of the obese cases in the control group (n ¼ 26, 24.1%) was three times greater than the obese premature ejaculators (Po0.005), and the number of PE patients were approximately two times greater than the control cases in the normal-weight class (Po0.001). This is the first prospective study that investigated the relationship between lifelong PE and obesity, and we found that patients with lifelong PE were leaner than the healthy control cases.

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Section: Discussionsupporting

confidence: 90%

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Gökçe

Ekmekçioğlu

2010

Int J Impot Res

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“…Similar results were found in men, where three studies reported a negative association between plasma DHEA-S and a central accumulation of body fat (55,56) and two other studies reported the opposite (57,59). The association between computed tomography-measured visceral adipose tissue areas and DHEA-S was negative in one study (56) and positive in the other (57).…”

Section: Obesity and Body Fat Distributionsupporting

confidence: 76%

“…Such data suggest that higher circulating DHEA is associated with lower body fat accumulation. Two studies out of six used more precise measures, such as body fat mass and percent body fat measured by hydrostatic weighing and confirmed these findings (56,57). These correlations were found in both pre-and postmenopausal women (52 -54), as well as Caucasian men of various ages (55 -57).…”

Section: Obesity and Body Fat Distributionmentioning

confidence: 62%

“…In men, the magnitude and direction of the association between DHEA-S and obesity is also equivocal. Seven studies found a significant association between plasma DHEA-S and measures of obesity (55 -61), two studies found that DHEA-S was negatively associated with measures of obesity (57,59), whereas five studies found the opposite (55,56,58,60). A number of studies also found no significant association (62 -67).…”

Section: Obesity and Body Fat Distributionmentioning

confidence: 99%

“…In men, all three studies where DHEA was measured found a significant negative association between DHEA levels and measures of abdominal fat distribution (55 -57), thus suggesting that low circulating DHEA is associated with a more central distribution of adipose tissue. Two studies (56,57) have examined the correlation between computed tomography measures of visceral adipose tissue area and plasma DHEA. These studies also reported a negative correlation, suggesting that low DHEA levels are associated with greater accumulation of fat within the abdominal cavity (Table 2).…”

Section: Obesity and Body Fat Distributionmentioning

confidence: 99%

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Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Tchernof

Labrie

2004

European Journal of Endocrinology

152

100

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The age-related decline in serum dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) has suggested that a relative deficiency of these steroids may be causally related to the development of chronic diseases generally associated with aging, including insulin resistance, obesity, cardiovascular disease, cancer, reductions of the immune defense, depression and a general deterioration in the sensation of well-being. The numerous studies which have focused on the link between DHEA and cardiovascular disease have generally been inconsistent, generating much debate and controversy on this issue. The present article is an analysis of studies on the relationship between endogenous DHEA or DHEA-S, obesity and cardiovascular disease risk, as well as DHEA treatment studies. Elevated plasma levels of free DHEA are associated with reduced obesity in both men and women, and with smaller abdominal body fat accumulations in men. However, contradictory results have been reported regarding the relationships between the sulfate ester DHEA-S and adiposity. Age differences in the populations studied may have been a confounding factor in these associations. On the other hand, DHEA-S level is not a predictor of cardiovascular disease endpoints in women, and appears to be a relatively weak one in men. DHEA intervention studies suggest that the effects of DHEA on serum lipids are, at best, modest or non-significant. The uncertainty as to whether endogenous and exogenous DHEA should be considered cardioprotective is related to discrepancies in the literature on this topic. Several studies may have been plagued by methodological problems such as low power, unreliable analytical methods, confounding factors or other differences in the populations studied. As a consequence, the original reports demonstrating dramatic effects of either endogenous or exogenous DHEA on cardiovascular disease risk have never been replicated. We propose that the effects of DHEA on cardiovascular disease risk (either favorable or unfavorable) should be considered to be much more modest than previously believed.

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Salivary estradiol and testosterone in filipino men: Diurnal patterns and relationships with adiposity

Gettler

McDade

Feranil

et al. 2014

American J Hum Biol

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Consistent with past research, our results indicate that adipose tissue is a significant site of E2 production in males but differ from a limited number of prior studies of young men in that we did not find lower T with increasing adiposity. Given E2's role in male hypothalamic-pituitary-gonadal function and complex interfaces with the immune system, these results have important implications for models of male life history as rates of overweight and obesity rise in populations around the world.

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Reduced testosterone and adrenal C19 steroid levels in obese men

Cited by 168 publications

References 32 publications

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Salivary estradiol and testosterone in filipino men: Diurnal patterns and relationships with adiposity

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