Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Abstract

Although both biological and psychological factors are important in the etiology, the exact pathogenesis of lifelong premature ejaculation (PE) remains to be clarified. Obesity is a worldwide epidemic that contributes to many chronic diseases. Obesity is associated with erectile dysfunction, but the relationship between obesity and PE has not yet been specifically investigated. The aim of this study was to evaluate the relationships of these two conditions. Between January 2008 and December 2009, we evaluated consecutive patients with lifelong PE in the urology outpatient clinic. Control cases without lifelong PE were selected randomly among cases attending the department of internal medicine for a checkup procedure. The age and sex of control group were matched with that of the study group. Body mass index (BMI) of each case was calculated using the World Health Organization criteria by the measurements of the physician instead of relying on verbal expressions. The mean (±s.d.) age of the premature ejaculators was 31.7±5.7 (range 21-51) years and in the control cases it was 32.3±6.7 (range 22-54) years. The comparison of the mean (±s.d.) weight between the study (74.1 ± 11.2 kg) and control groups (81.9 ± 6.4 kg) revealed a significant difference (Po0.001). The mean BMI of premature ejaculators (24.9 ± 3.4 kg m -2 ) was lower than the mean BMI of control (27.5±3.6 kg m -2 ; Po0.001). As the BMI increased, the number of patients decreased in the PE group. The number of the obese cases in the control group (n ¼ 26, 24.1%) was three times greater than the obese premature ejaculators (Po0.005), and the number of PE patients were approximately two times greater than the control cases in the normal-weight class (Po0.001). This is the first prospective study that investigated the relationship between lifelong PE and obesity, and we found that patients with lifelong PE were leaner than the healthy control cases.

Study of the Role of Body Mass Index and Serum Leptin as Potential Risk Factors in Patients with Lifelong Premature Ejaculation

“…This finding can be seen in line with Reas et al (2007) who demonstrated that accelerated weight gain occurs mainly during younger adulthood as it represents a critical time period due to ensuant lifestyle changes involving energy expenditure, dietary intake and they inaccurately assume their weight falls into a normal weight range [26] . Finally, the current results affirmed [17,27] .…”

Premature Ejaculation and Endocrine Disorders: A Literature Review

“…In their study evaluating 236 MetS patients and 567 controls, Corona et al [ 63 ] reported a higher prevalence of PE among MetS patients (22.7% vs. 3% controls). On the contrary, Gökçe and Ekmekcioglu [ 64 ] reported that PE patients were leaner than healthy controls, and that the number of PE patients decreased as BMI increased. Amato et al [ 65 ] developed a new sex-specific metabolic index, the visceral adiposity index (VAI), which is calculated from WC, BMI, TG, and high-density lipoprotein values.…”

“…The authors of that study also suggested that VAI is a useful index for assessing and calculating the risk of PE, and the relationship between adiposity and PE may be due to the increase in peripheral aromatization of androgens. The difference in the prevalence of PE in patients with MetS in the last two studies [ 64 66 ] may be due to regional and cultural differences. The differing prevalence of PE in patients with MetS may be due to the use of different definitions of PE, variations in the number of patients in each study, and the large inconsistency in the prevalence of hyperglycemia in these studies.…”

Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health

“…However, it has not yet been settled the degree of interrelation between erectile dysfunction and premature ejaculation ( 26 ). To further stimulate the discussion, premature ejaculation was reported to have an inverse relationship with obesity ( 27 ). These findings highlight the complex relationship between sexual and metabolic disorders.…”