Reduced status of plasma total antioxidant capacity in schizophrenia

Yao, Jeffrey; Reddy, Ravinder; McElhinny, L.G.; Kammen, Daniël P. van

doi:10.1016/s0920-9964(98)00030-9

Cited by 145 publications

(85 citation statements)

References 22 publications

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“…Owing to this property, the levels of serum uric acid deplete in condition of oxidative stress as observed in schizophrenics as compared to controls. Further in accordance with the study of Yao et al [40] who observed a trend of lower uric acid levels in relapsed patients relative to clinically stable chronic schizophrenics also had depleted levels. Cumulative attack by free radicals, due to substance abuse explains the depletion in uric acid levels [41].…”

Section: Discussionsupporting

confidence: 91%

Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Dadheech

Sharma

2012

Ind J Clin Biochem

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Section: Discussionsupporting

confidence: 91%

Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Dadheech

Sharma

2012

Ind J Clin Biochem

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“…Therefore, studies examining antioxidant parameters in patients with schizophrenia are confl icting. Some studies have shown increased antioxidant levels in patients with schizophrenia (23)(24)(25)(26), while some have shown a decrease (22,27,28), and still some have found no change (29)(30)(31). Our results showed an increase in oxidant levels and no change in antioxidants in patients with schizophrenia.…”

Section: Discussioncontrasting

confidence: 49%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

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“…Furthermore, some studies have differentiated enzymatic changes among the schizophrenia subtypes (Herken et al, 2001;Zhang et al, 2006a), and one study showed a linear correlation between antioxidant enzyme levels and positive symptom severity . The antioxidants uric acid (Yao et al, 1998b), albumin and bilirubin (Yao et al, 2000), and the plasma total antioxidant status (TAS) (Yao et al, 1998a) have also been reported to be lower in patients with schizophrenia than in controls. Albumin, bilirubin and uric acid were shown to be significantly lower in neuroleptic-naive patients with first-episode schizophrenia, results that were independent of smoking status (Reddy et al, 2003), thus strengthening the evidence for defective antioxidant defence as an early pathophysiological change associated with the disease, rather than a sequela of drug effects, chronic disease and smoking.…”

Section: Assays Of Oxidants and Antioxidantsmentioning

confidence: 99%

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Berk

Dean

et al. 2008

Int. J. Neuropsychopharm.

866

569

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Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.

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Reduced status of plasma total antioxidant capacity in schizophrenia

Cited by 145 publications

References 22 publications

Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Elevated nucleosome level and oxidative stress in schizophrenia patients

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

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