Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Dadheech, Gora; Sharma, Praveen

doi:10.1007/s12291-012-0193-z

Cited by 14 publications

(15 citation statements)

References 30 publications

(30 reference statements)

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“…Schizophrenia is associated with a complex pathophysiology and outcome of radical mediated neurotoxicity. Dadheech et al [29] demonstrated that the levels of endogenous antioxidants viz. GSH, bilirubin, total protein, albumin and uric acid, are disturbed in condition of schizophrenia which is an attempt to neutralize the ROS in body and reduce oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects

Pingmuangkaew

Tangvarasittichai

2014

Ind J Clin Biochem

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Abdominal obesity (AO) and metabolic syndrome (MetS) are associated with the cardiovascular disease and type 2 diabetes. Serum uric acid (SUA) is often elevated in subjects with the AO. We aimed to investigate the association of elevated SUA with the components of MetS, oxidative stress and TG/HDL-C ratio in AO subjects. This cross-sectional study used data from a Health Survey for Prevention of Hypertension and Type 2 Diabetes Mellitus in residents of two districts in Phitsanulok province, including 443 subjects. Anthropometric, blood pressure (BP) and biochemical variables were measured. We categorized the participants to two-group as 248 AO subjects (median age = 58, interquartile range 50.0-65.0 years) and 195 non-AO subjects (median age = 53, interquartile range 47.0-62.0 years). Waist circumference was significantly correlated with SystBP, DiastBP, Glu and SUA (P < 0.05) and SUA was significantly correlated with Glu, TG, HDL-C and TG/HDL-C ratio (P < 0.05). By using multiple logistic regression, we found the association of elevated SUA with abdominal obesity, hyperglycemia, hypertriglyceridemia, reduced HDL-C, elevated TG/HDL-C ratio, MetS and increased oxidative stress after adjusting for their covariates. Our study demonstrated that circulating UA is a major antioxidant and might help protect against free-radical oxidative damage. However, elevated SUA concentrations associated with oxidative stress, MetS, insulin resistance, and components of MetS. Then, SUA may be a marker of increased oxidative stress, insulin resistance and MetS, implying an increased risk of vascular disease and T2DM.

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Section: Discussionmentioning

confidence: 99%

Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects

Pingmuangkaew

Tangvarasittichai

2014

Ind J Clin Biochem

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“…For example, in a study of 50 participants with schizophrenia (aged 18–60) and 50 controls matched for age and sex, blood samples were collected to determine SOD, MDA, glutathione, and GPx levels; schizophrenia patients had significantly lower levels of SOD and GPx, but higher levels of MDA than controls, indicating increased OS [ 119 ]. Overall, evidence suggests that OS occurs in schizophrenia with an imbalance in the antioxidant defense mechanism and antioxidant enzyme impairment [ 120 , 121 ].…”

Section: Association Between Oxidative Stress and Schizophreniamentioning

confidence: 99%

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

Madireddy

2020

Brain Sciences

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The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery.

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“…Firstly, the levels of peripheral albumin, bilirubin and uric acid are susceptible to diet, but this study did not strictly control the dietary. Speaking of which , a previous study did control the dietary factors, but came up with analogous findings [28]. Besides, the three non-enzymatic antioxidants can be affected by many factors, such as weight, glucose and lipid metabolism [37,38].…”

Section: Solberg Et Al Showed That Differences On Alb Levels Betweenmentioning

confidence: 74%

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

Wen

Wang

et al. 2020

Preprint

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Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidant between schizophrenia patients and healthy controls. Methods: Peripheral UA, ALB and TBIL of 107 schizophrenic patients in acute stage and 101 in remission stage were measured respectively, so were 273 healthy controls. Results: The levels of UA ( P =0.020) and TBIL ( P <0.001) of schizophrenic patients in acute stage were higher than those of healthy controls, while the level of ALB ( P <0.001) was lower. Similar results were detected form schizophrenic patients in remission stage. Schizophrenic patients in acute stage were divided into antipsychotics-use subgroup (n=56) and antipsychotics-naïve/free subgroup (n=51). The level of UA ( P =0.001) in antipsychotics-use subgroup was higher than that in antipsychotics-naïve/free subgroup, while the level of TBIL ( P =0.002) was lower than that in antipsychotics-naïve/free subgroup. 77 schizophrenic patients in acute stage were followed up, and there was no significant difference in level of UA before and after treatment, but levels of ALB ( P <0.001) and TBIL ( P <0.001) decreased significantly after the treatment. Conclusion: This study demonstrated that the dysfunction of peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia. Keywords: Schizophrenia; Uric acid; Albumin; Total bilirubin

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Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia

Cited by 14 publications

References 30 publications

Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects

Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

Peripheral Non-enzymatic Antioxidants in Patients with Schizophrenia：A Case-control Study

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