Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects

Abstract

Abdominal obesity (AO) and metabolic syndrome (MetS) are associated with the cardiovascular disease and type 2 diabetes. Serum uric acid (SUA) is often elevated in subjects with the AO. We aimed to investigate the association of elevated SUA with the components of MetS, oxidative stress and TG/HDL-C ratio in AO subjects. This cross-sectional study used data from a Health Survey for Prevention of Hypertension and Type 2 Diabetes Mellitus in residents of two districts in Phitsanulok province, including 443 subjects. Anthropometric, blood pressure (BP) and biochemical variables were measured. We categorized the participants to two-group as 248 AO subjects (median age = 58, interquartile range 50.0-65.0 years) and 195 non-AO subjects (median age = 53, interquartile range 47.0-62.0 years). Waist circumference was significantly correlated with SystBP, DiastBP, Glu and SUA (P < 0.05) and SUA was significantly correlated with Glu, TG, HDL-C and TG/HDL-C ratio (P < 0.05). By using multiple logistic regression, we found the association of elevated SUA with abdominal obesity, hyperglycemia, hypertriglyceridemia, reduced HDL-C, elevated TG/HDL-C ratio, MetS and increased oxidative stress after adjusting for their covariates. Our study demonstrated that circulating UA is a major antioxidant and might help protect against free-radical oxidative damage. However, elevated SUA concentrations associated with oxidative stress, MetS, insulin resistance, and components of MetS. Then, SUA may be a marker of increased oxidative stress, insulin resistance and MetS, implying an increased risk of vascular disease and T2DM.

Effects of pre‐ or post‐exercise whey protein supplementation on oxidative stress and antioxidant enzymes in older women

“…The antioxidant activity of uric acid is not powerful when compared with hydrophilic vitamin C or hydrophobic vitamin E, based on its chemical structure . Moreover, elevated serum uric acid level is associated with OS and the risk of hypertension, diabetes, and cardiovascular disease . In this way, the function of uric acid in the human body is still unclear.…”

Relationship between oxidative stress and inflammation in hyperuricemia

“…Kuzkaya et al [33] verified in vitro experimental research that UA can prevent the uncoupling of nitric oxide synthase through purging peroxynitrite anions to increase NO synthesis for antioxidative purposes. However, an increasing number of studies [34,35] have proven that a high level of serum UA is the major determinant of the oxidative response in UA-related metabolic diseases. Xie et al [36] found that higher UA not only increased the expression of inflammatory cytokines, such as IL-6, intercellular adhesion molecule-1, TNF-α and monocyte chemoattractant protein, but also increased the formation of oxidants in human umbilical vein endothelial cells.…”

Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women

“…Furthermore, serum UA could predict the alteration of serum CRP concentrations in healthy population (21). In fact, serum UA has antioxidant properties in subjects with abdominal obesity and metabolic syndrome (22), and serum UA concentrations are correlated with biological antioxidant levels in the general population (23), moreover, serum UA is a plasma antioxidant to protect the cells against increased ROS activity (24). Oxidative stress plays an important role in the developments of placental-related diseases, and higher maternal homocysteine as an oxidative stress parameter is associated with risk of abortion or preterm birth in pregnant women (24).…”