Ren Wang, Chen Yin, Xiao-Xing Li, Xian-Zi Yang, Yang Yang, Mei-Yin Zhang, Hui-Yun Wang, X.F. Steven Zheng
Abstract:The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance of SOD2 in a large cohort of HBV-positive HCC tumors. Both SOD2 mRNA and protein are reduced in human primary HCCs compared with matching liver tissues. Consistently, the SOD2 DNA copy numbers are …
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